A postsynaptic terminal is the receiving part of the connection (synapse) between two nerve cells (neurons). The postsynaptic terminal membrane is less than 50 nanometers away and contains specialized receptors.
Neuroligins (NLs) are postsynaptic cell-adhesion molecules essential for normal synapse function. Neuroligins act as ligands for β-Neurexins, which are cell adhesion proteins located presynaptically. Neuroligin and β-neurexin "shake hands", resulting in the connection between two neurons and the production of a synapse. Neuroligins also affect the properties of neural networks by specifying synaptic functions, and they mediate signalling by recruiting and stabilizing key synaptic components. Neuroligins interact with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures. Neuroligin 1 localizes at excitatory synapses, neuroligin 2 at inhibitory synapses and neuroligin 3 at both. Reduction in the levels of neuroligins 1, 2 and 3 results in a strong reduction of inhibitory input but little reduction in excitatory input. Neuroligin 1 is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-03868 | Anti-NLGN1 (aa 119-295) polyclonal antibody | H | WB |
| CABT-B1609 | Anti-NLGN1 (phospho T739) polyclonal antibody | M, R | WB, IP |
The DLG3 gene encodes the synapse-associated protein 102 (SAP102), which is concentrated in the postsynaptic densities of excitatory synapses and involved in receptor-mediated synaptic transmission via binding to the NR2B subunit of the NMDA receptor.
| Cat. No | Product Name | Reactivity | Application |
| CPBT-57553RH | Anti-DLG3 (aa 108-157) polyclonal antibody | H | WB, ELISA |
| DPABH-03730 | Anti-DLG3 (aa 525-803) polyclonal antibody | H, M | IHC-P, WB, ICC/IF |
| DPABH-06722 | Anti-Human DLG3 polyclonal antibody | H, M, R | WB, IHC |
Gephyrin is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-607 | Anti-GPHN monoclonal antibody, clone 8D7 | H | WB, FC |
| DCABH-6362 | Anti-GPHN monoclonal antibody, clone FQS23762(C) | H, M, R | WB, IHC-P, FC |
| DCABH-7271 | Anti-GPHN monoclonal antibody, clone FQS23761 | H, M, R | WB, ICC/IF, IHC-P |
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a member of the membrane-associated guanylate kinase (MAGUK) family. It is a pivotal postsynaptic scaffolding protein in excitatory neurons. PSD-95 is a excellent marker for post synpatic mechanisms.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-3241 | Anti-DLG4 monoclonal antibody, clone 8F4-2C9 | C, H, M, R | WB, IHC, ICC/IF, FC |
| DCABH-8356 | Anti-DLG4 monoclonal antibody, clone 7H7-2D0 | H, M, R, Z | FC, WB, IHC-FoFr, ICC/IF, IP |
| DCABH-5788 | Anti-DLG4 monoclonal antibody, clone TS49-10 | H, M, R | WB, ICC/IF, IHC, IP, FC |
Homer1 protein is one of postsynaptic density proteins linking metabotropic glutamate receptors to other intracellular effectors mediating the effects of N-methyl-d-aspartate and aminohydroxymethyl isoxazole propionate receptors as well as the intracellular calcium stores.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-7937 | Anti-HOMER1 monoclonal antibody, clone FQS26410 | H, M, R | IP, WB, IHC-P |
| CABT-B1572 | Anti-HOMER1 polyclonal antibody | H, M, R | WB, ICC, IHC |
| CABT-BL4859 | Anti-HOMER1 (N-terminal) polyclonal antibody | H, M, R | WB, IHC |
The SHANK (SH3 and multiple ankyrin repeat domains) gene family encodes three homologous proteins (Shanks 1–3) that localize to dendrites of glutamatergic synapses throughout the brain, and serve as scaffolding proteins in the postsynaptic density. SHANK1 deletions cause high functional autism in males.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-4940 | Anti-SHANK1 monoclonal antibody, clone N470 | M | WB |
| DPABH-04213 | Anti-SHANK1 (aa 2100-2161) polyclonal antibody | H | WB, IHC-P |
The SHANK (SH3 and multiple ankyrin repeat domains) gene family encodes three homologous proteins (Shanks 1–3) that localize to dendrites of glutamatergic synapses throughout the brain, and serve as scaffolding proteins in the postsynaptic density. SHANK2 mutations are associated with autism spectrum disorder (ASD), moderate intellectual disability (ID), developmental delay, and mild motor deficits.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC1019 | Anti-SHANK2 (aa 1034-1124) polyclonal antibody | H | WB, ELISA |
| DPABH-09094 | Anti-SHANK2 (aa 886-916) polyclonal antibody | M | WB |
| CABT-B11378 | Anti-Rat Shank2 monoclonal antibody, clone T34c-7 | R | WB, IHC, IP |
The SHANK (SH3 and multiple ankyrin repeat domains) gene family encodes three homologous proteins (Shanks 1–3) that localize to dendrites of glutamatergic synapses throughout the brain, and serve as scaffolding proteins in the postsynaptic density. SHANK3 is strongly involved in the pathogenesis of autism spectrum disorder (ASD), and SHANK3 truncating mutations are associated with moderate to profound intellectual disability.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-02127 | Anti-Human SHANK3 polyclonal antibody | H, M | IP, WB |
| CABT-B1200 | Anti-SHANK3 (C-terminal half) monoclonal antibody, clone 27F3.4 | M | WB |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; G Goat; Ch Chicken
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