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Binding Capacities of Immunoglobulin Proteins

Antibody
Protein L
Protein A
Protein G
Protein A/G

Human IgG
s
s
s
s

Mouse IgG
s
s
s
s

Rabbit IgG
w
s
s
s

Goat IgG
nb
w
s
s

Rat IgG
s
w
m
m

Sheep IgG
nb
w
s
s

Bovine IgG
nb
w
s
s

Guinea Pig IgG
w
s
w
s

Hamster IgG
s
m
m
m

Pig IgG
s
s
w
s

Horse IgG
–
w
s
s

Donkey IgG
–
m
s
s

Dog IgG
–
s
w
s

Cat IgG
–
s
w
s

Monkey IgG (Rhesus)
–
s
s
s

Chicken IgG
nb
nb
nb
nb

Human IgM
s
w
nb
w

Human IgE
s
m
nb
m

Human IgD
s
nb
nb
nb

Human IgA
s
w
nb
w

Human IgG1
s
s
s
s

Human IgG2
s
s
s
s

Human IgG3
s
w
s
s

Human IgG4
s
s
s
s

Mouse IgG1
s
w
m
m

Mouse IgG2a
s
s
s
s

Mouse IgG2b
s
s
s
s

Mouse IgG3
s
s
s
s

Rat IgG1
s
w
m
m

Rat IgG2a
s
nb
s
s

Rat IgG2b
s
nb
w
w

Rat IgG2c
s
s
s
s

Bovine IgG1
nb
w
s
s

Bovine IgG2
nb
s
s
s

Sheep IgG1
nb
w
s
s

Sheep IgG2
nb
s
s
s

Goat IgG1
nb
w
s
s

Goat IgG2
nb
s
s
s

Horse IgG(ab)
–
w
nb
w

Horse IgG(c)
–
w
nb
w

Horse IgG(T)
–
nb
s
s

Mouse IgM
s
nb
nb
nb

Human IgA1
s
w
nb
w

Human IgA2
s
w
nb
w

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