Ionotropic receptors are membrane-spanning protein complexes that direct the coupling of the neurotransmitter receptor to the ion channel. They contain two functional domains: an extracellular site that binds neurotransmitters and a membrane-spanning domain that forms an ion channel. The neurotransmitter binding to the ionotropic receptor leads to a conformational change that is passed along to the closely associated ion channel, and as a result the channel properties are altered. This important feature of ionotropic receptors means that the modulation of ion channel properties varies with the length of time that the transmitter occupies the receptor. Therefore they mediate rapid-onset and rapidly reversible synaptic transmission, generally in millisecond orders.
Many ionotropic receptors are in the Cys-loop superfamily, which contains some venerable receptors such as the nicotinic ACh receptors, glycine receptors, 5-HT3 receptors, as well as some newly discovered members, such as the zinc-activated channels and the invertebrate GABA-gated cation channel.
The ionotropic glutamate receptors bind the neurotransmitter glutamate. They form tetramers with each subunit consisting of an extracellular amino terminal domain (ATD, which is involved tetramer assembly), an extracellular ligand binding domain (LBD, which binds glutamate), and a transmembrane domain (TMD, which forms the ion channel).
In addition, there are ATP-gated channels which open in response to binding the nucleotide ATP. They form trimers with two transmembrane helices per subunit and both the C and N termini on the intracellular side.
5HT3 receptors are expressed in native central and peripheral neurons where they are thought to play important roles in sensory processing and control of autonomic reflexes. Activation of the presynaptic 5HT3 receptors is associated with modulation in the release of neurotransmitters and neuropeptides such as acetylcholine, GABA, dopamine, glutamate, and vasoactive intestinal peptide (VIP).
| Cat. No | Product Name | Reactivity | Application |
| DCABH-11956 | Anti-HTR3A monoclonal antibody | H | WB, ELISA |
| DPABH-24919 | Anti-Human HTR3A polyclonal antibody | H, M, R | WB, IHC, FC, ELISA |
The nicotinic acetylcholine receptor (nAChR), is receptor polypeptide that respond to the neurotransmitter acetylcholine. It is a key player in neuronal communication, converts neurotransmitter binding into membrane electrical depolarization. This protein combines binding sites for the neurotransmitter acetylcholine (ACh) and a cationic transmembrane ion channel. The nAChR also binds the addictive drug nicotine. It mediates synaptic transmission at the junction between nerve and muscle cells and various types of nAChR are expressed in the brain.
| Cat. No | Product Name | Reactivity | Application |
| DMAB9588 | Anti-Nicotinic Acetylcholine Receptors monoclonal antibody, clone 270 | Ch | IP, WB, IHC |
Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. Diseases associated with ZACN include Amme Complex. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and ligand-gated ion channel activity.
| Cat. No | Product Name | Reactivity | Application |
| CABT-BL3827 | Anti-ZACN (aa 36-85) polyclonal antibody | H | WB |
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. GABAA receptors occur in all organisms that have a nervous system. To a limited extent the receptors can be found in non-neuronal tissues. Due to their wide distribution within the nervous system of mammals they play a role in virtually all brain functions.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-4209 | Anti-GABRA1 monoclonal antibody, clone FQS6512(3) | H | WB, IHC-P |
| DCABH-11645 | Anti-GABRA1 monoclonal antibody | H | WB, ELISA |
The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine. GlyR is an ionotropic receptor that produces its effects through chloride current. It is one of the most widely distributed inhibitory receptors in the central nervous system and has important roles in a variety of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brainstem.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-29009 | Anti-Glycine Receptor alpha 1 / alpha 2 (N-terminal) polyclonal antibody | H, M, R | IHC-Fr, WB, ICC/IF |
| CABT-B10334 | Anti-Human GLRA1 monoclonal antibody, clone 3F7 | H | WB, ELISA |
The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that is important in neurotransmission as well as in processes of synaptic plasticity in the mammalian superior colliculus (SC). There are two NMDA subunit gene families: NMDAR1 and NMDAR2. In vitro, a member of the NMDAR1 family is required for channel activity. The NMDAR1 subunits are the product of a single gene with three regions that may be variably spliced, encoding a short segment in the N-terminal region (N1) and two longer adjacent regions in the C terminus.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-3024 | Anti-GRIN1 monoclonal antibody, clone T419-59 | H, M, R | IHC-P, WB, ICC/IF |
| CABT-L3615 | Anti-Human GRIN1 (Phospho-Ser896) polyclonal antibody | H, M, R | WB, IHC, ELISA |
| CABT-L3614 | Anti-Human GRIN1 (Phospho-Ser890) polyclonal antibody | H, M, R | IHC, IF, ELISA |
The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that is important in neurotransmission as well as in processes of synaptic plasticity in the mammalian superior colliculus (SC). NMDA receptor channels are heterotetramers composed of two molecules of the key receptor subunit NMDAR1 (GRIN1) and two drawn from one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.
| Cat. No | Product Name | Reactivity | Application |
| CABT-L3619 | Anti-Human GRIN2B (Phospho-Tyr1336) polyclonal antibody | H, M, R | IHC, ELISA, WB |
| DPAB-DC1466 | Anti-GRIN2B (aa 127-236) polyclonal antibody | H | WB, ELISA |
| DPABH-01571 | Anti-Human GRIN2B polyclonal antibody | H, M, R | WB, IHC, IF, IP, FC, ELISA |
P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. In the central nervous system, activation of P2X receptors allows calcium to enter neurons and this can evoke slower neuromodulatory responses such as the trafficking of receptors for the neurotransmitter glutamate. P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-16169 | Anti-P2RX7 (internal region) polyclonal antibody | H | IHC-P, WB, ELISA |
| DPABH-19254 | Anti-P2RX7 (aa 13-26) polyclonal antibody | M | IHC-P, WB |
| CABT-54654RM | Anti-P2RX7 monoclonal antibody, clone Hano43 | M | FC, IF |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; Ch Chicken
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