Dengue Virus Antigens

Dengue Fever virus, abbreviated as DENV, belongs to the family of Flaviviridae of genus of Flavivirus. DENV transmitted mainly by the mosquitos often causes mosquito-borne tropical disease. The host infected with DENV has a symptom, such as a high fever, vomiting, headache, muscle and joint pains, and a characteristic skin rash, typically begin three to fourteen days after infection. People often take two to seven days to recover from DENV associated diseases, but in some cases, that people infected with DENV may develop into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. Figure 1 shows the outer surface of whole Dengue Fever virus:

Model of Dengue Fever virus

Fig. 1 Model of Dengue Fever virus

Dengue Fever virus is a RNA virus and homogeneous to West Nile virus, Japanese encephalitis virus and yellow fever virus. Genome of the dengue virus contains about 11,000 nucleotide bases, which code three different types of protein molecules (C, prM and E) that form the virus particle and seven other types of protein molecules (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5) that are found in infected host cells only and are required for life cycle of the virus.

There are five serotypes of Dengue Fever virus of which the first four are referred to as DENV-1, DENV-2, DENV-3 and DENV-4. In 2013, another type, the fifth type has been found. Among those five serotypes, their antigenicity differs from each other even though they have a similar symptom after hosts infected with them. Figure 2 shows that inner structure of Dengue Fever virus:

Molecular Model of Dengue Fever virus

Fig. 2 Molecular Model of Dengue Fever virus

Dengue fever is a viral disease transmitted by mosquitoes in many tropical and subtropical parts of the world. An estimated 390 million dengue infections occur worldwide each year, with about 96 million resulting in illness. Many scientists are working to develop vaccines that can prevent dengue fever virus. Now Creative Diagnostics can provide DENV Antigens, Antibodies and ELISA kits to help researchers to do the preliminary evaluation. Our Phd level scientists are always ready to help you find the most suitable reagents.

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