Creative Diagnostics has developed a range of fibrotic agents for use in the study of neurodegenerative diseases.These agents include alpha-synuclein, beta-synuclein, gamma-synuclein, tau, beta-amyloid, SOD1, and more. Our mission is to be the world leader in the development and supply of active pathology-inducing protein aggregates to help scientists develop disease models and accelerate drug discovery in neurodegenerative diseases.
Fig 1. SOD Pre-Formed Fibrils (PFF)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive, fatal neurodegenerative disease marked with the loss of upper and lower motor neurons. The superoxide dismutase (SOD1) gene, the major antioxidant gene, was the first gene to be associated with a familial form of ALS. Other genes associated with inherited ALS include TDP-43 and FUS. Numerous experiments have shown that full-length apo SOD1 can be converted into amyloid fibrils by incubation with reducing agents in vitro. Importantly, SOD1 protofibrils formed in vitro can incorporate into cells and spread between cells. Furthermore, SOD1 protofibrils produced under reducing conditions share the same pathological properties as ALS inclusion bodies, such as the ability to induce mitochondrial damage, cause neuroinflammation and activate microglia to trigger ALS neurodegeneration. Therefore, the structural determination of SOD1 protofibrils is important for understanding the pathogenic mechanisms of SOD1 in familial and sporadic ALS.
Fig 2. Oxidative misfolding of Cu/Zn superoxide dismutase triggered by non-canonical intramolecular disulfide formation.
(Anzai I, et al., 2020)
Creative Diagnostics has launched SOD1 Preformed Fibres (PFF) products for ALS research. Please refer to the SOD1 Preformed Fibres product list below to find the most relevant preformed fiber product for your project. If you require a bespoke preformed prototype product, our experienced scientific staff can select, customize and create the type of product you need for your current research.
| Cat. No. | Product Name | |
| PFF26 | Human Recombinant Superoxide dismutase Protein Pre-Formed Fibrils | Inquiry |
Creative Diagnostics has developed a range of SOD1-preformed fiber products for neurodegenerative disease research. Our SOD1 proto-fiber products can help scientists develop disease models and test drug candidates. If you are interested in any of our products, please do not hesitate to contact us for a more detailed description. If you cannot find the product you are looking for, please contact us.
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