Zebrafish Antibodies

Zebrafish is an emerging immune model used in areas ranging from drug testing to cancer research due to their striking genomic similarity to humans, regenerative abilities and shortened life cycle. Creative diagnostics is now proud to offer a comprehensive and rigorously validated collection of antibodies validated in zebrafish samples. The in-demand 'zebrafish' antibodies are expected to contribute to immune studies.

Zebrafish Validated Antibodies

Our team decided to produce antibodies against key immune molecules in zebrafish to enhance the research within the fish scientific community as well as mammalian immune disorders researches. The currently offered antibodies are for research use only and have been tested on zebrafish samples in various applications.
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  • Broad range of target proteins. Immunogen sequence designed to work specifically for zebrafish proteins
  • Antibodies validated using various immunoassays and are available in different sizes.
  • Different conjugation available.

Benefits of the Zebrafish

Rapid Embryological Development

Comparing to other vertebrates, zebrafish produce hundreds of eggs at weekly intervals and they grow at an extremely fast rate, developing as much in a day as a human embryo develops in one month.

Fully Sequenced Genome

  • Results shows 70% of protein-coding human genes are related to genes found in zebrafish and 84% of genes known to be associated with human disease have a zebrafish counterpart.
  • The fully sequenced zebrafish genome enabled scientists to create mutations in more than 14,000 genes to study their function. And the zebrafish mutants have been produced to model human diseases such as: Alzheimer`s disease, Congenital heart disease, Polycystic kidney disease, Duchenne muscular dystrophy, Leukaemia, etc.

Animal Models of Human Disease

  • Zebrafish has an adaptive immune system which has features that are much like essential human elements.
  • Many of the genes and critical pathways are highly conserved between human and zebrafish which made zebrafish an excellent model for many research topics including cell biology, cancer research, epigenetic, metabolism, neuroscience, signal transduction and stem cell development.

Permeable, Transparent and Manipulation-Friendly Embryos

  • The permeable embryos make them ideal for screening large numbers of toxicology samples or drug candidates.
  • The initially transparent embryo made them suitable for studies of cell or tissue function and behavior since most cellular pathways are identical between human and fish.
  • The ex-vivo fertilized embryos are relatively large which made them amenable to manipulation by a variety of physical, chemical, and genetic means.

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Multi-genic screening of target genes

Inject plasmids harboring gene of interests into embryos and monitor the accelerated tumor onset in adult fish.

Modeling metastatic behavior

Tumor metastasis can be followed through the injection of GFP-labelled cell cultures in transparent zebrafish.

Epigenetic mechanisms Studies

One method of studying cancer epigenetics in fish is to perform ChIP upon FACs sorted embryos followed by sequencing or expression profiling.

Phenotypic screening

Chemical libraries can be screened for activity in live zebrafish embryos using early embryonic phenotypic markers in 96 well plates. Toxicity can also be addressed in parallel during the same screening.

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