Glutamatergic neuron is a nerve cell which sends messages by using the neurotransmitter glutamate. Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as a key neuromodulator to control synapse and circuit function over a wide range of spatial and temporal scales. Glutamate pathways are linked to many other neurotransmitter pathways, and glutamate receptors are found throughout the brain and spinal cord in neurons and glia.
Glutamate concentrations in the extracellular space are low and tightly controlled by a large number of mechanisms at the synapse. Perturbations to this regulatory system can have deleterious effects such as excess release of glutamate, which can induce hyperexcitability in post-synaptic neurons to the point of excitotoxicity and cell death (cytotoxicity). Consequently, glutamate dysfunction has profound effects both in disease and injury.
GS is present predominantly in the brain, kidneys, and liver. GS in the brain participates in the metabolic regulation of glutamate, the detoxification of brain ammonia, the assimilation of ammonia, recyclization of neurotransmitters, and termination of neurotransmitter signals. Glutamine synthetase activity has been shown to be a useful marker of astrocytes.
| Cat. No | Product Name | Reactivity | Application |
| CABT-L1329 | Anti-Human Glutamine Synthetase monoclonal antibody, clone 8I0M27 | H, M, R | FC, ICC, IF, WB |
| CABT-B9212 | Anti-Human Glutamine Synthetase monoclonal antibody, clone 7 | H, M, R | WB, IHC, Bioimaging, IF, IP |
| CABT-L3005 | Anti-Human Glutamine Synthetase monoclonal antibody, clone JID697 | H | IHC |
The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that is important in neurotransmission as well as in processes of synaptic plasticity in the mammalian superior colliculus (SC). There are two NMDA subunit gene families: NMDAR1 and NMDAR2. In vitro, a member of the NMDAR1 family is required for channel activity. The NMDAR1 subunits are the product of a single gene with three regions that may be variably spliced, encoding a short segment in the N-terminal region (N1) and two longer adjacent regions in the C terminus.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-3024 | Anti-GRIN1 monoclonal antibody, clone T419-59 | H, M, R | IHC-P, WB, ICC/IF |
| CABT-L3615 | Anti-Human GRIN1 (Phospho-Ser896) polyclonal antibody | H, M, R | WB, IHC, ELISA |
| CABT-L3614 | Anti-Human GRIN1 (Phospho-Ser890) polyclonal antibody | H, M, R | IHC, IF, ELISA |
The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that is important in neurotransmission as well as in processes of synaptic plasticity in the mammalian superior colliculus (SC). NMDA receptor channels are heterotetramers composed of two molecules of the key receptor subunit NMDAR1 (GRIN1) and two drawn from one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.
| Cat. No | Product Name | Reactivity | Application |
| CABT-L3619 | Anti-Human GRIN2B (Phospho-Tyr1336) polyclonal antibody | H, M, R | IHC, ELISA, WB |
| DPAB-DC1466 | Anti-GRIN2B (aa 127-236) polyclonal antibody | H | WB, ELISA |
| DPABH-01571 | Anti-Human GRIN2B polyclonal antibody | H, M, R | WB, IHC, IF, IP, FC, ELISA |
VGLUTs are key molecules for the incorporation of glutamate in synaptic vesicles across the nervous system. They are VGLUT1-3 that are encoded by the solute vector gene SLC17A6-8. VGLUT1 was originally named brain-specific Na+-dependent inorganic phosphate co-transporter (BNPI), which is mainly expressed in brain. VGLUT1 is a specific biochemical marker of glutamatergic neurons and glutamatergic synapses.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-3015 | Anti-SLC17A7 monoclonal antibody, clone O39-0 | H, R | WB, IHC-P, FC |
| DCABH-6739 | Anti-SLC17A7 monoclonal antibody, clone FQS21064 | H, M, R | WB |
VGLUTs are key molecules for the incorporation of glutamate in synaptic vesicles across the nervous system. They are VGLUT1-3 that are encoded by the solute vector gene SLC17A6-8. VGLUT2 (SLC17A6) is expressed in glutamatergic neurons of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe. In addition, VGLUT2 functions as a differential marker for hippocampal output neurons.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-3017 | Anti-SLC17A6 monoclonal antibody, clone T30-30 | H, M, R | IHC-P, WB |
| CABT-29495MR | Anti-SLC17A6 monoclonal antibody, clone 9H0.3 | M, R | ICC/IF, IHC-Fr, WB |
| CABT-B1629 | Anti-VGLUT2 polyclonal antibody | M, R | WB, IHC |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail
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