Oligodendrocyte Marker Antibodies

Oligodendrocytes are a type of neuroglia whose main functions are to provide support and insulation to axons in the central nervous system of some vertebrates. Oligodendrocytes arise during development from oligodendrocyte precursor cells (OPCs), which can be identified by their expression of a number of antigens, including the ganglioside GD3, the NG2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit (PDGF-alphaR). Mature oligodendrocytes are broadly classified into either myelinating or non-myelinating satellite oligodendrocytes. Precursors and both mature types are typically identified by their expression of the transcription factor OLIG2.

Oligodendrocyte Marker

OLIG2

A2B5

NG2/MCSP/CSPG4

MBP

Oligodendrocyte Marker O4

OLIG2

Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor. OLIG2 is mostly expressed in restricted domains of the brain and spinal cord ventricular zone which give rise to oligodendrocytes and specific types of neurons.

Cat. No	Product Name	Reactivity	Application
DCABH-1507	Anti-OLIG2 monoclonal antibody, clone 4D0	H	WB, IHC-P
CABT-B1762	Anti-OLIG2 (N-terminal) polyclonal antibody	H, M, R	WB, IHC-P, ICC, IP
CABT-L602	Anti-OLIG2 monoclonal antibody, clone TQ18-13	H, M, R	WB, IHC

See all OLIG2 antibodies

A2B5

A2B5 is a cell surface ganglioside epitope expressed in developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells. It is an excellent marker for thymic epithelial cells, oligodendrocyte progenitors and neuroendocrine cells.

Cat. No	Product Name	Reactivity	Application
DMABT-H21663	Anti-A2B5 monoclonal antibody, clone B3C6-206	Ch	FC, ICC, IF, IHC
DMABT-Z59125	Anti-A2B5 monoclonal antibody, clone 207	H, M, R, Ch	FC, IHC-Fr, ICC, IF

See all A2B5 antibodies

NG2/MCSP/CSPG4

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. It is a hallmark protein of oligodendrocyte progenitor cells (OPCs).

Cat. No	Product Name	Reactivity	Application
DCABH-3530	Anti-CSPG4 monoclonal antibody, clone FQS0206	H	WB, IHC-P, FC
DCABH-8976	Anti-CSPG4 monoclonal antibody, clone 243.49	M, R	WB, IHC
DPABH-28489	Anti-CSPG4 (aa 300-400) polyclonal antibody	M, R	IHC-P, WB, ICC/IF

See all NG2/MCSP/CSPG4 antibodies

MBP

Myelin basic protein (MBP) is a major myelin constituent produced by oligodendrocytes in the central nervous system (CNS). Expression of MBP was considered to be a marker for oligodendrocyte differentiation and myelination in the developing CNS and it has long been considered as a marker of active demyelination.

Cat. No	Product Name	Reactivity	Application
CABT-50963MM	Anti-MBP monoclonal antibody, clone 10	B	IHC-Fr, ELISA, WB
DCABH-8201	Anti-MBP monoclonal antibody, clone TNJ 00	H	IHC-Fr, ELISA, WB
DCABH-8200	Anti-MBP monoclonal antibody, clone TNJ-05	H, M, R	ICC/IF, IHC-P, IHC-F, WB

See all MBP antibodies

Oligodendrocyte Marker O4

Oligodendrocyte Marker O4 is a differentiation marker on the surface of oligodendrocyte precursors in the central nervous system.

Cat. No	Product Name	Reactivity	Application
CABT-B12377	Anti-Human O4 monoclonal antibody, clone P5 [Biotin]	R	FC
CABT-B12378	Anti-Human O4 monoclonal antibody, clone P5	R	FC

See all Oligodendrocyte Marker O4 antibodies

SOX10

Sox proteins are characterized by possession of a DNA-binding domain with similarity to the high-mobility group domain of the sex determining factor SRY. During development Sox10 first appeared in the forming neural crest and continued to be expressed as these cells contributed to the forming PNS and finally differentiated into Schwann cells. In the CNS, Sox10 transcripts were originally confined to glial precursors and later detected in oligodendrocytes of the adult brain.

Cat. No	Product Name	Reactivity	Application
DCABH-4478	Anti-SOX10 monoclonal antibody, clone TE315-15	H, M, R	WB, ICC/IF, IHC
DCABH-7295	Anti-SOX10 monoclonal antibody, clone 3F8C6	H	WB, FC
DCABH-13560	Anti-SOX10 monoclonal antibody	H	WB, ELISA

See all SOX10 antibodies

PDGFRA

PDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, or CD140a, is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation.

Cat. No	Product Name	Reactivity	Application
CABT-L3961	Anti-Human PDGFRA (Phospho-Tyr849) polyclonal antibody	H, M, R	WB, ELISA
DCABH-2917	Anti-PDGFRA monoclonal antibody, clone KG215-7	H, M, R	WB, ICC, IHC, FC
DCABH-5616	Anti-PDGFRA monoclonal antibody, clone BQB6	M	FC, FuncS, WB, IHC-Fr

See all PDGFRA antibodies

APC

Adenomatous Polyposis Coli (APC) is a +TIP protein that promotes microtubule assembly and has been studied extensively for its roles in biology and disease. It is highly expressed in the developing brain. Its normal biological functions include cytoskeletal regulation in cell and axon migration, cell polarity, and adhesion. APC enhances proliferation of oligodendroglial progenitor cells (OPCs) and is essential for oligodendrocyte differentiation in a cell-autonomous manner.

Cat. No	Product Name	Reactivity	Application
CABT-B1454	Anti-APC (C-terminal) monoclonal antibody, clone D-BQD 39.0	H	IF, IHC-P, ICC, WB
CABT-L3252	Anti-Human APC (Phospho-Ser2054) polyclonal antibody	H	WB, ELISA, IHC
DCABH-8818	Anti-APC monoclonal antibody, clone TD72-14	H, R	WB, ICC, IP

See all APC antibodies

CNPase

CNPase is found in high levels in the brain and peripheral nerve, almost exclusively in oligodendrocytes and Schwann cells. CNPase is the third most abundant protein found in the central nervous system myelin. It is found early in oligodendrocyte development and continues to be found in adult animals.

Cat. No	Product Name	Reactivity	Application
DCABH-6204	Anti-CNP monoclonal antibody, clone KG21-36	H, M, R	WB, ICC, IHC, FC
DCABH-7676	Anti-CNP monoclonal antibody, clone FQS24116	H, M, R	WB
DPABH-21466	Anti-CNP (aa 80-84) polyclonal antibody	H, M, R	WB

See all CNPase antibodies

Nogo-A/RTN4

Nogo-A is expressed in oligodendrocytes, in the inner and outer loops of myelin sheaths, and in some neuronal populations such as dorsal root ganglion cells, retinal ganglion cells, and ventral horn neurons in spinal cord. Nogo-A was originally identified because of its ability to prevent axonal regrowth and sprouting. Treatment with antibodies recognizing the N-terminal epitope of Nogo-A (IN-1) resulted in improved regenerative fiber outgrowth in rats with spinal cord trauma.

Cat. No	Product Name	Reactivity	Application
DCABH-6446	Anti-RTN4 monoclonal antibody, clone FQS23377	H, M, R	WB, FC
DPABH-22179	Anti-Human RTN4 polyclonal antibody	H, M	WB, IHC, IF, ELISA
CPBT-66139RH	Anti-RTN4 (C-terminal) polyclonal antibody	H, M, R	IHC-P, WB

See all Nogo-A/RTN4 antibodies

Myelin PLP

Myelin proteolipid protein (PLP) is identified as a specific and largely heat-resistant marker for detection of food contaminations by CNS tissue. PLP is a component of oligodendritic glial sheaths of neuronal processes that is specifically expressed in the CNS.

Cat. No	Product Name	Reactivity	Application
DCABH-783	Anti-PLP1 monoclonal antibody, clone qmqd2	H	WB, IHC
DCABH-7669	Anti-PLP1 monoclonal antibody, clone FQS23786(3)(C)	H, M, R	IHC-P, IP
DPAB-DC2280	Anti-PLP1 (aa 177-232) polyclonal antibody	H	WB, ELISA

See all Myelin PLP antibodies

TPPP/p25

Tubulin polymerization promoting protein (TPPP/p25) is located in mature OG and aggregates in oligodendroglial cytoplasmic inclusions in multiple system atrophy. Distinct and increased expression of TPPP/p25 in MS renders it a potential prognostic and diagnostic marker of MS.

Cat. No	Product Name	Reactivity	Application
CPAB-Z45091RH	Anti-TPPP (aa 27-219) polyclonal antibody	H	WB
DCABH-1255	Anti-TPPP monoclonal antibody, clone FQS4426	H	WB, IHC-P, IP
DPABH-06735	Anti-Human TPPP polyclonal antibody	H, M	WB, ELISA, IHC

See all TPPP/p25 antibodies

OMgp

Oligodendrocyte-myelin glycoprotein (OMgp) is expressed on the surface of oligodendrocytes and neurones and is thought to inhibit axonal regeneration after brain injury in adult, like Nogo and myelin-associated glycoprotein (MAG). Previous study suggests that OMgp is a late marker of myelination, which could be implicated in the arrest of oligodendrocyte proliferation, arrest of myelination or compaction of myelin.

Cat. No	Product Name	Reactivity	Application
DCABH-16283	Anti-OMG monoclonal antibody	H	WB, ELISA
DPABH-17897	Anti-OMG (aa 299-311) polyclonal antibody	H	ELISA, WB

See all OMgp antibodies

Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; G Goat; Ch Chicken

References

Kuhlmann, T. , et al. "Nogo-A is a Reliable Oligodendroglial Marker in Adult Human and Mouse CNS and in Demyelinated Lesions." Journal of Neuropathology & Experimental Neurology 66.3(2007):238.
Liu, Z. , et al. "Specific Marker Expression and Cell State of Schwann Cells during Culture In Vitro." PLOS ONE (2015).
Preitner, N. , et al. "APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly." Cell 158.2(2014):368-382.
"Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligo- dendroglial changes in multiple sclerosis. " Current Medical Literature Multiple Sclerosis (2011).
Villmann, C. , et al. "Myelin proteolipid protein (PLP) as a marker antigen of central nervous system contaminations for routine food control. " Journal of Agricultural & Food Chemistry 55.17(2007):7114-23.

Neuroscience Antibodies