Cyclic nucleotide-gated (CNG) channels are ion channels which are activated by the binding of cGMP or cAMP. Cyclic nucleotides directly activate CNG channels by binding to a site on the channel protein. The dependence of channel activation on the ligand concentration is steep, indicating that several, most probably four, molecules of the ligand are required to fully open the channels. All CNG channels respond to some extent to both cAMP and cGMP. The channels are important cellular switches which transduce changes in intracellular concentrations of cyclic nucleotides into changes of the membrane potential and the Ca2+ concentration.
CNG channels play a central role in the signal transduction pathways of vision and olfaction. Structurally, the channels belong to the superfamily of pore-loop cation channels. They share a common domain structure with hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Eag-like K+ channels.
CNGA1, also known as RP49 or CNCG1, is a member of the subfamily of cyclic nucleotide-gated cation channels. The CNGA1 gene, located at chromosome 4p12, contains 11 exons. CNGA1 encodes the α-subunit of the rod cGMP-gated channel (CNG) and is predominantly expressed in rod photoreceptors. CNGA1 consists of six putative transmembrane domains, a pore region and a cGMP-binding domain.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-26726 | Anti-Human CNG1 polyclonal antibody | H | WB |
Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein. Among 3 functional CNG isoforms (CNGA1-A3), CNGA2 has a much higher sensitivity to cAMP than other CNG isoforms. Reports show that CNGA2 mediate the adenosine-induced Ca2+ influx in these cells, and that CNG channels may play an important role in endothelium-dependent vasorelaxation in response to A2 adenosine receptor agonists.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-19585 | Anti-CNGA2 (aa 412-653) polyclonal antibody | H | WB, IHC-P |
Cyclic nucleotide-gated cation channel alpha-3, also known as CNGA3, is a member of the cyclic nucleotide-gated cation channel protein family, which is required for normal vision and olfactory signal transduction. CNGA3 is expressed in cone photoreceptors and is necessary for color vision. Missense mutations in this gene are associated with rod monochromacy and segregate in an autosomal recessive pattern. Two alternatively-spliced transcripts encoding different isoforms have been described.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-18883 | Anti-CNGA3 (C-terminal) polyclonal antibody | H | IHC, WB |
| CABT-B8387 | Anti-CNGA3 (aa590-694) polyclonal antibody | H | WB, ELISA |
Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein. The CNGB1 gene locus consists of at least 33 exons encoding several splice variants. Shorter variants of the subunit lacking the GARP part are present in the native olfactory CNG channel (CNGB1b) and have been identified in sperm cells and other tissues. A CNGB1-deficient mouse model covering all potential CNGB1 splice variants was generated by deleting exon 26, which encodes the pore-forming region and the S6 segment. These mice show an impairment of both vision and olfaction.
| Cat. No | Product Name | Reactivity | Application |
| CABT-BL1102 | Anti-CNGB1 (aa 287-299) polyclonal antibody | H, R | WB |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; G Goat; Ch Chicken
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