Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Typical PD symptoms include motor features (bradykinesia, postural disturbances, rigidity or tremor or both) and non-motor features (hyposmia, sleep disorders, autonomic, neuropsychiatric and sensory symptoms).
The main pathological characteristics of PD are cell death in the brain's basal ganglia (affecting up to 70% of the dopamine-secreting neurons in the substantia nigra pars compacta by the end of life). In most patients the early stagesIn Parkinson's disease, alpha-synuclein becomes misfolded and clump together with other alpha-synuclein. Cells are unable to remove these clumps, and the alpha synuclein becomes cytotoxic, damaging the cells. Loss of neurons is accompanied by the death of astrocytes (star-shaped glial cells) and a significant increase in the number of microglia (another type of glial cell) in the substantia nigra. The diagnosis of PD depends mostly on clinical motor findings, which appear when half of the substantia nigra (SN) dopamine neurons are lost. PD is often diagnosed clinically when disease progression is already advanced. Hence the continuing need to identify reliable biomarkers that can facilitate the clinical diagnosis of PD.
Tau proteins are proteins that perform the function of stabilizing microtubules. These proteins are abundant in nerve cells and are present to a much lesser degree in oligodendrocytes and astrocytes. Therefore, Tau proteins are also as a mature neural marker. In addition, it is also a markers for the early diagnosis of Alzheimer's disease (AD).
| Cat. No | Product Name | Reactivity | Application |
| DPABH-13578 | Anti-Human Tau polyclonal antibody | H | WB, IHC, ICC/IF |
| DPABH-28964 | Anti-Tau (Phospho S416) polyclonal antibody | M, R | WB |
| DCABH-9990 | Anti-Tau (Phospho S199) monoclonal antibody, clone FQS3512Z | H, M, R | WB |
α-Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD pathogenesis in a number of ways, but it is generally thought that its aberrant soluble oligomeric conformations, termed protofibrils, are the toxic species that mediate disruption of cellular homeostasis and neuronal death, through effects on various intracellular targets, including synaptic function. Phosphorylated α-synuclein combined with total α-synuclein concentrations in CSF may help in distinguishing PD from atypical parkinsonisms.
| Cat. No | Product Name | Reactivity | Application |
| CABT-B1398 | Anti-α-Synuclein (phospho S129) monoclonal antibody, clone 92B | H, M | EM, WB, IHC-P, IF, ICC |
| CABT-B1476 | Anti-SNCA (aa 115-122) monoclonal antibody, clone MC600 | H | IHC, WB |
| CABT-26489MH | Anti-SNCA monoclonal antibody, clone Tzo625 | H | WB, IHC-P |
The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer's disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-5236 | Anti-PARK7 monoclonal antibody, clone TO18-32 | H, M, R | WB, ICC/IF, IHC, IP, FC |
| DPAB-DC410 | Anti-PARK7 (aa 1-100) polyclonal antibody | H | WB, ELISA |
| DPABH-14112 | Anti-PARK7 polyclonal antibody | H, M, R | ICC/IF, WB, IHC-P |
The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine density and affect long-term potentiation (LTP).
| Cat. No | Product Name | Reactivity | Application |
| DCABH-2709 | Anti-Human Amyloid beta precursor protein (Phospho T743) monoclonal antibody, clone FQS937(3) | H, M, R | WB, IP |
| DMAB6617 | Anti-Amyloid β monoclonal antibody, clone 13C3 | H | IHC-P, WB, IP |
| DMAB6618 | Anti-Amyloid β monoclonal antibody, clone 83F2 | H | IHC-P, WB, ELISA |
LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and Crohn's disease. Expression of LRRK2 mutants implicated in autosomal dominant Parkinson's disease causes shortening and simplification of the dendritic tree in vivo and in cultured neurons.
| Cat. No | Product Name | Reactivity | Application |
| CABT-L1450 | Anti-Human phospho LRRK2 (Ser935) monoclonal antibody, clone 4I9M20 | H | ICC, IHC-P, IF, WB |
| CABT-Z613R | Anti-Human LRRK2 Monoclonal Antibody, clone NKGG3(d52-3) | H, M | ICC/IF, WB, IP |
| CABT-Z614R | Anti-Human LRRK2 (Phospho T1410) Monoclonal Antibody, clone NKGS5-36-6 | H | WB |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail
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