VHH Antibody Production

What is VHH?

VHH is the variable domain of camelid heavy chain antibodies (HcAbs), and it is the smallest antigen-binding functional fragments, also called single-domain antibody (sdAb). VHH molecules are a type of miniature, engineered antibody. VHH shows some unique advantages versus conventional antibodies since they combine desirable features of monoclonal antibodies with some of the beneficial properties of small molecule drugs.

Fig. 1 Comparison between traditional IgG antibody and camelid heavy-chain antibody.
(Sun S.; et al. Int J Nanomedicine. 2021)

Advantages of VHH Antibodies

• Superior chemical and physical properties accommodates diverse research, therapeutic, and diagnostic applications.
• Smaller VHH size allows for easier delivery into tissues and through physiological barriers not accessible to conventional antibodies.
• The single-domain structure also enables molecular manipulation.

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What we offer?

Why choose Creative Diagnostics?

Choose our Naïve or immune library

Use our naive libraries or develop your own phage display immune library.

Wide variety of antigens

Peptide, protein, hapten, whole cell… We design and produce/synthesize any possible antigens for you.

High diversity camelid antibody libraries

Our VHH libraries contain at least 10^7-9 different variants.

IP free

You get the full ownership of the VHH sequence generated!