Serotonin is an important neurotransmitter with multiple functions in the whole central nervous system. Its synthesis, however, is restricted to a very limited number of cells in the brainstem raphe nuclei with a vast axonal network. Serotonergic neurons are involved in sleep-wakefulness cycles and, like locus coeruleus noradrenergic neurons, stop firing during rapid-eye–movement sleep. These cells express markers of the serotonin lineage such as the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 2, the serotonin transporter, and the transcription factor Pet1.
ETS domain transcription factor, Pet-1, that is expressed in a small number of tissues, including the brain. Pet-1 is an early and precise marker of central serotonin neurons.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-13854 | Anti-FEV (aa 149-198) polyclonal antibody | H | WB |
| DPAB-DC2357 | Anti-FEV (aa 31-130) polyclonal antibody | H | WB, ELISA |
Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase. Tryptophan hydroxylases catalyze the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5-HTP), which is subsequently decarboxylated to form the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT). It is important for synthesizing indoleamine neurotransmitters and related compounds in the body and brain, including serotonin, melatonin, tryptamine, N-methyltryptamine, and N, N-dimethyltryptamine.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-9108 | Anti-TPH1 monoclonal antibody, clone TD64-18 | H, M, R | WB, ICC/IF, IHC, IP, FC |
| DPABH-01566 | Anti-Human TPH1 polyclonal antibody | H, M | WB, ELISA |
Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase which is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-27086 | Anti-Human TPH2 polyclonal antibody | H, R | WB, ELISA |
| CABT-L1643 | Anti-Human TPH2 monoclonal antibody, clone 0I2M7 | H, M, R | WB, ICC/IF |
| DPABH-14559 | Anti-TPH2 (aa 16-29) polyclonal antibody | H, M, R | WB |
Serotonin Transporter (SERT) is a member of the Neurotransmitter-Sodium Symporter (NSS) family and is closely related to transporters for norepinephrine and dopamine, NET, and DAT, respectively. The function of SERT is to take up serotonin (5-HT) released by the activity of serotonergic neurons. It is located presynaptically on serotonergic axon terminals and are believed to serve as an index of serotonergic innervation.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC2896 | Anti-SLC6A4 (aa 181-252) polyclonal antibody | H | WB, ELISA |
| DCABH-7012 | Anti-Human SLC6A4 monoclonal antibody, clone 27I3M8 | H, M, R | WB, ICC/IF |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail
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