Ca2+ channels in many different cell types activate on membrane depolarization and mediate Ca2+ influx in response to action potentials and subthreshold depolarizing signals. Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential changes into intracellular Ca2+ transients that initiate many physiological events. There are ten members of the voltage-gated Ca2+ channel family in mammals, and they serve distinct roles in cellular signal transduction. The CaV1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The CaV2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The CaV3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons.
CaV1 channels initiate excitation-contraction coupling in skeletal, cardiac, and smooth muscle. CaV1.1 channels in the transverse tubules are thought to interact directly with the ryanodine-sensitive Ca2+ release channels (RyR1) of the sarcoplasmic reticulum and the voltage-driven conformational changes in their voltage-sensing domains are thought to directly induce activation of RyR1. Functional expression of the CaV1.1 channel in skeletal muscle requires its RyR1 binding partner.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC3233 | Anti-CACNA1S (aa 1743-1838) polyclonal antibody | H | WB, ELISA |
| DPABH-23459 | Anti-Human CACNA1S polyclonal antibody | H | WB, IHC, ELISA |
CaV1 channels initiate excitation-contraction coupling in skeletal, cardiac, and smooth muscle. In contrast to skeletal muscle, entry of Ca2+ is required for excitation-contraction coupling in cardiac myocytes, and Ca2+ entry via CaV1.2 channels triggers activation of the RyR2 and initiates Ca2+-induced Ca2+-release, activation of actomyosin, and contraction.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC3224 | Anti-CACNA1C (aa 2039-2138) polyclonal antibody | H, R | WB, ELISA |
| CABT-B9883 | Anti-Human CACNA1C monoclonal antibody, clone 5E21 | H | WB, ELISA |
CaV1 channels initiate excitation-contraction coupling in skeletal, cardiac, and smooth muscle. In auditory hair cells, CaV1.3 channels conduct the L-type Ca2+ currents that trigger neurotransmitter release. Deletion of the gene encoding CaV1.3 channels causes deafness in mice. CaV1.3 channels are regulated by multiple interacting proteins, which may be important in tuning their activity to fit the specific requirements of hair cells transmitting auditory information at different frequencies.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-18117 | Anti-Human CACNA1D polyclonal antibody | H | WB, IHC, IF, ELISA |
CaV1 channels initiate excitation-contraction coupling in skeletal, cardiac, and smooth muscle. In photoreceptors, CaV1.4 channels are primarily responsible for Ca2+ entry that triggers exocytosis of neurotransmitters. Mutations in the CaV1.4 channel in humans lead to stationary night blindness.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-10807 | Anti-CACNA1F monoclonal antibody, clone 4C3 | H | WB, ELISA |
| DPAB-DC3232 | Anti-CACNA1F (aa 1878-1977) polyclonal antibody | H | WB, ELISA |
In the nervous system, CaV2.1 channels conducting P/Q-type Ca2+ currents and CaV2.2 channels conducting N-type Ca2+ currents are the predominant pathways for Ca2+ entry initiating fast release of classical neurotransmitters like glutamate, acetylcholine, and GABA.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-18101 | Anti-CACNA1A (cytoplasmic domain) polyclonal antibody | H | WB, IHC |
| CABT-L1945 | Anti-Rat CACNA1A (2150-2210) polyclonal antibody | R, M | WB, IHC |
In the nervous system, CaV2.1 channels conducting P/Q-type Ca2+ currents and CaV2.2 channels conducting N-type Ca2+ currents are the predominant pathways for Ca2+ entry initiating fast release of classical neurotransmitters like glutamate, acetylcholine, and GABA.
| Cat. No | Product Name | Reactivity | Application |
| DPAB2869RM | Anti-CaV2.2 (aa 851-867) polyclonal antibody | R | WB, IHC, ICC, IP |
Cav2.3 channels belong to the group of high voltage-activated (HVA) voltagegated calcium channels (VGCCs) and are responsible for Ca2+ influx into neuronal, neuroendocrine and other cells. They mediate the major portion of native R-type currents, which are characterized by their resistance to most organic Ca2+ channel antagonists and sensitivity to the tarantula toxin SNX-482. In addition, Cav2.3 channels are among the most sensitive molecular targets of Zn2+ currently known and expressed in many Zn2+-enriched tissues, suggesting that they are involved in the modulatory actions of endogenous Zn2+.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC2311 | Anti-CACNA1E polyclonal antibody | H, M, R | WB |
Ca2+ channels of the CaV3 subfamily conduct T-type Ca2+ currents. These Ca2+ currents are activated at comparatively negative membrane potentials, in the same range as Na+ currents in most cells, and they have fast voltage-dependent inactivation compared to other Ca2+ currents. CaV3 channels are important in repetitively firing tissues. It has been shown that knock down or blockade of Cav3.1 inhibits cell proliferation of human pulmonary artery smooth muscle cells (PASMCs) in vitro. In addition, Cav3.1 has also been found to be the predominant T-channel that promotes oxygenation-induced closure of the rat ductus arteriosus in VSMCs.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC1501 | Anti-CACNA1G polyclonal antibody | H, R | WB |
| DPAB-DC3689 | Anti-CACNA1G polyclonal antibody | H | IHC-P |
Ca2+ channels of the CaV3 subfamily conduct T-type Ca2+ currents. These Ca2+ currents are activated at comparatively negative membrane potentials, in the same range as Na+ currents in most cells, and they have fast voltage-dependent inactivation compared to other Ca2+ currents. CaV3 channels are important in repetitively firing tissues. Cav3.2 is necessary for acute pain perception, as well as mechanical and cold allodynia in mice. Being found throughout sensory pathways, from excitatory primary afferent neurons up to pain matrix structures, it is a promising target for analgesics.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-23423 | Anti-Human CACNA1H polyclonal antibody | H | WB, ELISA, ICC/IF |
| DPABH-26563 | Anti-Human CACNA1H polyclonal antibody | H | WB |
Ca2+ channels of the CaV3 subfamily conduct T-type Ca2+ currents. These Ca2+ currents are activated at comparatively negative membrane potentials, in the same range as Na+ currents in most cells, and they have fast voltage-dependent inactivation compared to other Ca2+ currents. CaV3 channels are important in repetitively firing tissues.
| Cat. No | Product Name | Reactivity | Application |
| CABT-B9154 | Anti-Human CACNA1I polyclonal antibody | H, M, R | IHC |
| CABT-B9884 | Anti-Human CACNA1I monoclonal antibody, clone 3G6 | H | WB, ELISA |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; Ch Chicken
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