Herpes simplex virus, abbreviated as HSV, is a member of the herpesvirus family, and a species that infects humans only. HSV has two major serotypes: HSV-1 and HSV-2. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. HSV-1 mainly infects up part of human body, including mouth, lips, eyes, brain and waist. When people infect by HSV, they often have a latent stage without showing any symptom; HSV-2 invaded the body below the waist, mainly genital part and thus this serotype has been spread through sex. After people suffering from herpes simplex virus, the lesion in body will produce grain-like size of the blisters, such as the occurrence of a single or cluster of small blisters, which usually consists about 10 grain-like size of the blisters. The skin around the blister turns red, and it produces a slight itching and fever. This blister if not treated, after a few days later, will crack the formation of erosion, and then gradually recovered. Figure 1 shows the schematic model of HIV particle:
Fig. 1 the Schematic Model of Herpes Simplex Virus
The genome of herpes simplex virus consists of a double-stranded linear DNA. The genomes of HSV-1 and HSV-2 are complex and contain two unique regions called the long unique region (UL) and the short unique region (US). Of the 74 known ORFs, UL contains 56 viral genes, whereas US contains only 12. Transcription of HSV genes is catalyzed by RNA polymerase II of the infected host. Immediate early genes, which encode proteins that regulate the expression of early and late viral genes, are the first to be expressed following infection. Early gene expression follows, to allow the synthesis of enzymes involved in DNA replication and the production of certain envelope glycoproteins.
Creative Diagnostics is a leading manufacturer of high quality herpes simplex virus antigens. We carry HSV type 1, type 2, HSV type 1 Glycoprotein, HSV type 1 Glycoprotein G, HSV type 2 Glycoprotein D, HSV type 2 Glycoprotein G and HSV type 8 Mosaic protein. Please feel free to contact our sales representative if you have any questions.