Neural Transcription Factors Antibodies

Transcription factors are proteins which bind to DNA in the nucleus to switch on or off the genes which characterize specific cell types. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism.

The early steps of neural development in the vertebrate embryo are regulated by sets of transcription factors that control the induction of proliferative, pluripotent neural precursors, the expansion of neural plate stem cells, and their transition to differentiating neural progenitors. These early steps of neural development are critical for producing a pool of multipotent cells that later give rise to the multitude of neurons and glia in the central nervous system that have diverse and distinct functions, and are selectively affected in a number of human neurodegenerative diseases.

Neural Transcription Factors

Brn3a

The POU domain transcription factors Brn3a, Brn3b and Brn3c are required for the proper development of sensory ganglia, retinal ganglion cells, and inner ear hair cells, respectively. The POU domain transcription factors Brn3a and Brn3b have been shown to be expressed in the trigeminal, dorsal root and inner ear sensory ganglia during mouse embryogenesis. Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Brn3a controls survival and differentiation of sensory neurons by regulation of different downstream genes. Deletion of Brn3a results in a significant loss of spiral ganglion neurons and defects in their migration.

Cat. No	Product Name	Reactivity	Application
DCABH-9987	Anti-POU4F1 monoclonal antibody, clone FQ2083Z	H, M, R	WB, IHC-P, ICC/IF, FC, IP
DPABH-27911	Anti-Human POU4F1 Polyclonal Antibody	H, M, R	WB, ELISA

See all Brn3a antibodies

BMI1

Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene. Bmi1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. The Bmi-1 expression interacts with several signaling containing Wnt, Akt, Notch, Hedgehog and receptor tyrosine kinase (RTK) pathway. Bmi-1 is also indicated as a key factor in controlling Th2 cell differentiation and development by stabilizing GATA transcription factors.

Cat. No	Product Name	Reactivity	Application
DCABH-1882	Anti-BMI1 monoclonal antibody, clone FQS4856(3)	H, R	WB, IHC-P, ICC/IF
DCABH-7504	Anti-BMI1 monoclonal antibody, clone 330G7	M	WB, IHC-Fr, IP
DCABH-14718	Anti-BMI1 monoclonal antibody, clone 4F4	H	WB, IHC-P, IF, ELISA, FC

See all BMI1 antibodies

FOXG1

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene. This gene belongs to the forkhead family of transcription factors that is characterized by a distinct forkhead domain. It has been shown to play a role in the development of the brain and telencephalon. Changes involving the FOXG1 gene cause FOXG1 syndrome, a rare disorder characterized by impaired development and structural brain abnormalities.

Cat. No	Product Name	Reactivity	Application
DPAB-DC1010	Anti-Human FOXG1 polyclonal antibody	H	WB, ELISA
CABT-L1309	Anti-Human FOXG1 monoclonal antibody, clone 3I8M3	H, M	ICC, WB

See all FOXG1 antibodies

GLI1

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. The Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription. Gli Proteins transcriptional regulation is tissue specific for many targets. For example, Gli1 in primary keratinocytes upregulates FOXM1 whereas in mesenchymal C3H10T1/2 cells it has been shown to upregulate platelet-derived growth factor receptor PDGFRa.

Cat. No	Product Name	Reactivity	Application
DCABH-3112	Anti-Gli1 monoclonal antibody, clone KG10-19	H, M, R	WB, IHC, ICC
DPABH-04183	Anti-Human GLI1 polyclonal antibody	H,M, R	WB, IF, IHC
DCABH-11744	Anti-GLI1 monoclonal antibody, clone 4D9	H	WB, IF, ELISA

See all GLI1 antibodies

HES1

HES1 is expressed in both neuroepithelial cells and radial glial cells, both neural stem cells. Hes1 expression, along with that of Hes5, covers the majority of the developing embryo at embryonic day 10.5. HES1 influences the maintenance of certain stem cells and progenitor cells. Specifically, HES1 influences the timing of differentiation by repressing bHLH activators, and determines binary cell fate.

Cat. No	Product Name	Reactivity	Application
CABT-L725	Anti-HES1 monoclonal antibody, clone TD17-32	H, M, R	WB, FC, ICC/IF, IHC
DPAB-DC1611	Anti-HES1 (aa 36-142) polyclonal antibody	M	WB, ELISA
CABT-RM152	Anti-HES1 monoclonal antibody, clone IT406B	H, M	IHC, ELISA

See all HES1 antibodies

Islet 1

Islet1 (ISL1) is a HD transcription factor belonging to the Lin/Isl/Mec-like (LIM) conserved zinc finger domain class. In vertebrates, motor neurons require Islet1 for their determination, survival and subsequent subtype specification. In addition, Islet1 plays a role in specification of mammalian sensory neuron subtypes

Cat. No	Product Name	Reactivity	Application
DCABH-6468	Anti-ISL1 monoclonal antibody, clone TD16-75	H, M	WB, IP, ICC/IF
DCABH-12045	Anti-ISL1 monoclonal antibody, clone 2I0	H	WB, IHC-P, IF, ELISA
CABT-B680	Anti-Isl1 polyclonal antibody	Z	IHC, WB

See all Islet 1 antibodies

OLIG2

Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor. OLIG2 is mostly expressed in restricted domains of the brain and spinal cord ventricular zone which give rise to oligodendrocytes and specific types of neurons.

Cat. No	Product Name	Reactivity	Application
DCABH-1507	Anti-OLIG2 monoclonal antibody, clone 4D0	H	WB, IHC-P
CABT-B1762	Anti-OLIG2 (N-terminal) polyclonal antibody	H, M, R	WB, IHC-P, ICC, IP
CABT-L602	Anti-OLIG2 monoclonal antibody, clone TQ18-13	H, M, R	WB, IHC

See all OLIG2 antibodies

PAX6

PAX6 is a member of the Pax gene family which is responsible for carrying the genetic information that will encode the Pax-6 protein. It plays a important role in the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues.

Cat. No	Product Name	Reactivity	Application
CABT-29261MH	Anti-PAX6 monoclonal antibody, clone QBY6J437	H	ELISA, IHC-P, WB
DCABY-1282	Anti-PAX6 monoclonal antibody, clone 204DU26.3.3	H	WB, IF
DPABH-25926	Anti-Human PAX6 polyclonal antibody	H, M	WB, IHC, IF, FC, ELISA

See all PAX6 antibodies

SOX2

SOX2, a HMG box transcription factor, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. SOX2 belongs to the family of SOXB1 factors and is a pivotal regulator of maintenance and induction of both PSCs and neural progenitor cells.

Cat. No	Product Name	Reactivity	Application
DMABT-H23512	Anti-SOX2 monoclonal antibody, clone Cukdf	H	FC, ELISA, IHC-P, ICC, WB
DCABH-2131	Anti-SOX2 monoclonal antibody, clone 4B3	H	WB, ELISA, IHC-P
DCABH-5662	Anti-SOX2 monoclonal antibody, clone 31H6	H, M	IHC-P, IP, WB, FC, ICC/IF

See all SOX2 antibodies

SOX10

Sox proteins are characterized by possession of a DNA-binding domain with similarity to the high-mobility group domain of the sex determining factor SRY. During development Sox10 first appeared in the forming neural crest and continued to be expressed as these cells contributed to the forming PNS and finally differentiated into Schwann cells. In the CNS, Sox10 transcripts were originally confined to glial precursors and later detected in oligodendrocytes of the adult brain.

Cat. No	Product Name	Reactivity	Application
DCABH-4478	Anti-SOX10 monoclonal antibody, clone TE315-15	H, M, R	WB, ICC/IF, IHC
DCABH-7295	Anti-SOX10 monoclonal antibody, clone 3F8C6	H	WB, FC
DCABH-13560	Anti-SOX10 monoclonal antibody	H	WB, ELISA

See all SOX10 antibodies

Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail

References

Huang, E. J. , et al. "Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons." Development 128.13(2001):2421-2432.
Lee, H. K. , H. S. Lee , and S. A. Moody . "Neural Transcription Factors: from Embryos to Neural Stem Cells." Molecules & Cells (2014).
Moreno, R. L. , and A. B. Ribera . "Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability." Neural Development 9.1(2014):19.

Neuroscience Antibodies