Ca2+ channels in many different cell types activate on membrane depolarization and mediate Ca2+ influx in response to action potentials and subthreshold depolarizing signals. There are two main types of calcium channels; voltage-gated calcium channels, which open in response to changes in membrane potential and ligand-gated calcium channels. Ligand-gated calcium channels are opened by the binding of a ligand such as a neurotransmitter to the receptor. Types of ligand-gated calcium channels include IP3 receptors, ryanodine receptors, and two-pore channels.
P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. P2X receptors are calcium perme- able ligand-gated ion channels acti- vated by ATP. P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-16169 | Anti-P2RX7 (internal region) polyclonal antibody | H | IHC-P, WB, ELISA |
| DPABH-19254 | Anti-P2RX7 (aa 13-26) polyclonal antibody | M | IHC-P, WB |
| CABT-54654RM | Anti-P2RX7 monoclonal antibody, clone Hano43 | M | FC, IF |
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC1752 | Anti-ITPR1 (aa 2470-2577) polyclonal antibody | H | WB, ELISA |
| DPABH-09480 | Anti-ITPR1 (C-terminal) polyclonal antibody | H | WB, IHC, ELISA |
| CABT-L3736 | Anti-Human ITPR1 (Phospho-Ser1764) polyclonal antibody | H, M, R | IHC, ELISA |
Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are responsible for the release of Ca2+ from intracellular stores during excitation-contraction coupling in both cardiac and skeletal muscle.
| Cat. No | Product Name | Reactivity | Application |
| DMAB9535 | Anti-alpha And β Ryanodine Receptors monoclonal antibody, clone 34C | Ch | IP, WB, IHC |
Two-pore channels (TPCs) are an ancient family of ion channels that are unusual because they are found, not at the cell surface, but spanning the membranes of acidic organelles such as endosomes and lysosomes. These organelles mediate biomolecule transport and breakdown, and serve as stores of calcium ions1 (Ca2+). TPCs are key for several organellar functions — releasing Ca2+ into the cytoplasm to control trafficking of material such as receptor proteins and viruses, for instance, and stabilizing junctions with other organelles.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-28150 | Anti-TPCN1 (C-terminal) polyclonal antibody | H, M, R | WB, IHC |
| DPABH-19383 | Anti-TPCN1 (aa 72-121) polyclonal antibody | H, Z | ICC/IF, WB |
Two-pore channels (TPCs) are an ancient family of ion channels that are unusual because they are found, not at the cell surface, but spanning the membranes of acidic organelles such as endosomes and lysosomes. These organelles mediate biomolecule transport and breakdown, and serve as stores of calcium ions1 (Ca2+). TPCs are key for several organellar functions — releasing Ca2+ into the cytoplasm to control trafficking of material such as receptor proteins and viruses, for instance, and stabilizing junctions with other organelles.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-14039 | Anti-TPCN2 (N-terminal) polyclonal antibody | H | WB, IHC-P |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; Ch Chicken
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