Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Gephyrin aa 700 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q9NQX3
Applications
Application Notes
WB: 1/1000 - 1/5000; IHC-P: 1/50 - 1/100; Flow Cyt: 1/10 - 1/100;
Target
Alternative Names
GPHN; gephyrin; KIAA1385; GPH; GEPH; GPHRYN;
Product Background
Antigen Description
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Pathway
GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Molybdenum cofactor biosynthesis, organism-specific biosystem; molybdenum cofactor biosynthesis, conserved biosystem;
Citations
Publication ()
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COA
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