Creative Diagnostics has developed key gamma-synuclein preformed fibrils (PFFs) to better mimic the naturally occurring pathology and pathological processes of neurodegenerative diseases, helping you research psychiatric disorders such as Parkinson's disease. It also provides the basis for more effective tumor marker development techniques. Our technical team has many years of experience in the development of preformed proto-fiber products and will be your trusted partner.
Fig 1. Gamma-synuclein preformed fibrils (PFFs)
Gamma-synuclein is a protein encoded in humans by the SNCG gene and is one of three members of the synuclein family (α-synuclein/SNCA, β-synuclein/SNCB, and SNCG). Gamma-synuclein is mainly found in the peripheral nervous system (primary sensory, sympathetic, and motor neurons) and in the retina, and is commonly expressed in breast tumors. It is also found in the brain, ovarian tumors, and olfactory epithelial cells. γ-Synuclein is also a marker for tumorigenesis. It has been implicated in neurodegenerative disease pathogenesis. Changes in the expression of γ-synuclein have been observed in the retina of patients with Alzheimer's disease. γ-Synuclein is thought to exist in a naturally unfolded conformation and readily aggregates in solution to form small soluble oligomers. These inclusions are present in neurons and synapses in the amygdala and substantia nigra of the human brain that contain Lewy bodies. Accumulation of gamma-synuclein is also seen in some cases of ALS, where it can accumulate in inclusion bodies and lead to motor neuron death. α- and γ-synuclein are thought to interact and promote aggregation of each other.
Fig 2. γ-Synuclein initiates α-synuclein aggregation. (Surgucheva I, et al., 2012)
Creative Diagnostics offers the following types of Gamma Synuclein Preformed Fibrils (PFFs). We are also developing a range of novel protofibrils for neurodegenerative disease research. We are committed to facilitating your experimental research by providing model tools to better study neurodegenerative diseases. Our product types include but are not limited to the following:
Creative Diagnostics has developed a range of preformed protofibrils for use in neurodegenerative disease research. Our gamma-synuclein-preformed protofibril products can help scientists develop disease models and test drug candidates. If you are interested in any of our products, please do not hesitate to contact us for a more detailed description. If you cannot find what you need, please contact us.
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