Dopaminergic neuron is a nerve cell which sends messages by using the neurotransmitter dopamine. Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and contains both redox available neuromelanin and a high iron content. Although their numbers are few, these dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement and a broad array of behavioral processes such as mood, reward, addiction, and stress.
Tyrosine hydroxylase (TH) is a member of the aromatic amino acid hydroxylase (AAAH) family. It is expressed throughout the central nervous system (CNS) and catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). Tyrosine hydroxylase is a marker for dopamine, norepinephrine, and epinephrine-containing (catecholamine) neurons and endocrine cells.
| Cat. No | Product Name | Reactivity | Application |
| CABT-B1144 | Anti-Tyrosine Hydroxylase (C-terminal) monoclonal antibody, clone 20G9.3 | H, R | IHC-P, WB |
| CABT-BL3567 | Anti-TH (Phospho S8) polyclonal antibody | H | WB, IHC-P, ELISA |
| CABT-L4150 | Anti-Human TH (Phospho-Ser19) polyclonal antibody | H, M, R | WB, IHC, IF, ELISA |
Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that is responsible for binding to folic acid and its derivatives, which becomes crucial during fetal development. It is a GPI-anchored cell surface molecule, specifically marks midbrain dopaminergic neurons (mesDA) neural progenitors and immature mesDA neurons.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-1731 | Anti-FOLR1 monoclonal antibody, clone FQS5819(3) | H, M, R | WB |
| DPABH-00367 | Anti-FOLR1 (aa 7-234) polyclonal antibody | H | WB, IHC-P, ICC/IF |
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, alcoholism, and substance use disorder.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-9267 | Anti-SLC6A3 monoclonal antibody, clone iEBU-MPPQ | H, R | IHC, WB, ICC/IF |
| DCABH-2865 | Anti-SLC6A3 monoclonal antibody, clone FQS8974 | H | WB, IHC-P, FC |
| DPAB-DC2895 | Anti-SLC6A3 (aa 161-237) polyclonal antibody | H | WB, ELISA |
LIM homeobox transcription factor 1 alpha (Lmx1a) is required for the development of midbrain dopaminergic neurons (mesDA), roof plate formation, and cortical hem development. It is a bona-fide mesDA lineage marker.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-02078 | Anti-Mouse LMX1A (C-terminal) polyclonal antibody | M | WB |
| DPABH-27913 | Anti-LMX1A (aa 1-100) polyclonal antibody | H, M, R | WB, ICC/IF |
LIM homeobox transcription factor 1 bata (Lmx1b) is required for the specification and maintenance of mDA neurons, primarily due to its role in isthmic organizer development that is essential for the induction of mDA neurons.
| Cat. No | Product Name | Reactivity | Application |
| DPABH-23756 | Anti-LMX1B (aa 64-77) polyclonal antibody | H | WB, IHC-P |
| DPABH-02089 | Anti-LMX1B (C-terminal) polyclonal antibody | H, M, R | WB, ICC/IF |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail
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