γ-Aminobutyric acid (GABA) is an abundant inhibitory neurotransmitter, and GABAergic neurons constitute~10% to 30% of the total neuronal population in the central nervous system depending on the species. A considerable number of subtypes of GABAergic interneurons diversify modes of neuron circuit assembly and physiological function. In particular, cortical inhibition locally provided by GABAergic interneurons plays a principal role not only in the overall balance of neuronal excitability but also synaptic interaction, spiking, synchrony, and oscillation in a neural ensemble.
Glutamate decarboxylase 1 (brain, 67kDa) (GAD67), also known as GAD1 is a human gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. GAD67 is considered an excellent marker for GABAergic neurons.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC1232 | Anti-GAD1 (full length) polyclonal antibody | H | IHC, WB |
| DPABH-12453 | Anti-Human GAD1 polyclonal antibody | H, M, R | WB, IP, IF, ELISA |
| DPABH-20152 | Anti-GAD1 (aa 526-537) polyclonal antibody | H, M, R | IHC-P, WB |
GAD2 encodes the islet cell specific (65 kDa) form of glutamic acid decarboxylase (GAD65), a prevalent autoantigen in T1D. GAD65 appears to be localized in nerve terminals and responds to short-term changes in demand for transmitter GABA. GAD65 is considered an excellent marker for GABAergic neurons.
| Cat. No | Product Name | Reactivity | Application |
| CABT-37787MH | Anti-GAD2 monoclonal antibody, clone 255 | H, M, R | WB, IP, FC, RIA |
| DPABH-02352 | Anti-GAD2 (aa 515-528) polyclonal antibody | H | WB, IHC-P |
GABAB receptors (GABABR) are broadly expressed in the nervous system and play an important role in neuronal excitability. GABAB receptors are G protein-coupled receptors that mediate slow and prolonged inhibitory action, via activation of Gαi/o-type proteins. In the brain, GABAB receptors are located both pre- and postsynaptically. Activation of presynaptic GABAB receptors inhibits neurotransmitter release from presynaptic terminals. There are two subunits of the receptor, GABAB1 and GABAB2, and these appear to assemble as heterodimers in neuronal membranes by linking up by their intracellular C termini.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-3026 | Anti-GABBR1 monoclonal antibody, clone T04B-50 | H, M, R | WB, ICC/IF |
| DPABH-25060 | Anti-GABBR1 (N-terminal) polyclonal antibody | H, M, R | WB, IHC-P, IP, ELISA |
| DPAB-DC4259 | Anti-GABBR1 (aa 33-54) polyclonal antibody | H | WB |
GABAB receptors (GABABR) are broadly expressed in the nervous system and play an important role in neuronal excitability. GABAB receptors are G protein-coupled receptors that mediate slow and prolonged inhibitory action, via activation of Gαi/o-type proteins. In the brain, GABAB receptors are located both pre- and postsynaptically. Activation of presynaptic GABAB receptors inhibits neurotransmitter release from presynaptic terminals. There are two subunits of the receptor, GABAB1 and GABAB2, and these appear to assemble as heterodimers in neuronal membranes by linking up by their intracellular C termini.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-7321 | Anti-GABBR2 monoclonal antibody, clone 6H8G8 | H | WB, ICC/IF, IHC-P |
| DPAB-DC4260 | Anti-GABBR2 (N-terminal) polyclonal antibody | H | WB |
γ-Aminobutyric Acid Transporter 1 (GAT1) is a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. GAT-1 is localized almost exclusively to axon terminals forming symmetric synaptic contacts and, in neocortex, to some astrocytic processes.
| Cat. No | Product Name | Reactivity | Application |
| CABT-BL5699 | Anti-SLC6A1 polyclonal antibody | H, M | ICC/IF, WB, IHC-FoFr |
| CABT-BL5700 | Anti-SLC6A1 polyclonal antibody | H | WB, IHC |
Vesicular inhibitory amino acid transporter is a membrane protein which is involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. It is localized in synaptic vesicles of glycinergic as well as GABAergic neurons.
| Cat. No | Product Name | Reactivity | Application |
| DPAB2403RH | Anti-SLC32A1 (C-terminal) polyclonal antibody | H | IF |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail
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