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Polyclonal Antibodies

Polyclonal antibody (pAb) is a group of immunoglobulins derived from plasmocyte secretion following the activation of heterologous antigen (macromolecular antigen, hapten conjugate). These antibodies recognise and bind to numerous epitopes of one antigen and hence can engage in lattices with the antigens and precipitate reaction. pAbs are used for different analyses, diagnostics and therapeutic purposes.

Creative Diagnostics provides broad portfolio of pAbs includes 1,000s of targets to support your project. Our pAbs are used in many applications including WB, flow cytometry, ELISA, IHC, and IF.

Find the right antibody from Creative Diagnostics

Popular Polyclonal Antibody Products

Anti-Human BAD (Phospho-Ser91/128) polyclonal antibody

Anti-Human BRF1 Polyclonal Antibody

Rabbit Anti-CCNC Polyclonal Antibody

Anti-CD276 Polyclonal Antibody

Rabbit Anti-Human CDA Polyclonal Antibody

Anti-Human DOK3 Polyclonal Antibody

Rabbit Anti-ELF3 Polyclonal Antibody

Anti-Histone H4 (acetyl K8) polyclonal antibody

Rabbit Anti-IL13 Polyclonal Antibody

Rabbit Anti-Human PIK3AP1 Polyclonal Antibody

Rabbit Anti-RAG2 Polyclonal Antibody

Anti-SFN Polyclonal Antibody

Creative Diagnostics also offer high quality secondary polyclonal antibody products.

Reactivity

Non-Fluorescent Conjugates

Fluorescent Conjugates

Target Ig Class

Anti Venom Polyclonal Antibody

The clinical judgment in treating snakebite comes down to choosing the correct antivenom and dose, based on snake species identification. Immunoassays such as ELISA measure and characterize particular venom, verifying snake identification and prescribing antivenom. Additionally, measuring free venom in the patient after treatment helps assess if sufficient antivenom was administered. Immunoassays can also evaluate the cross-reactivity of different antivenoms.

We offer a variety of polyclonal antibodies against snake venom, and you can browse more related products here.

Targets	Cat. No.	Product Name
Vipera Venom	DPAB-JX2371341	Sheep Anti-Vipera l atastei Venom Polyclonal Antibody	Inquiry
Pseudechis Venom	DPAB-JX2371312	Sheep Anti-Pseudechis Venom Polyclonal Antibody	Inquiry
Oxyuranus Venom	DPAB-JX2371311	Sheep Anti-Oxyuranus Venom Polyclonal Antibody	Inquiry
Notechis Venom	DPAB-JX2371336	Sheep Anti-Notechis Venom Polyclonal Antibody	Inquiry
Leiurus Venom	DPAB-JX2371330	Sheep Anti-Leiurus quinquestriatus Venom Polyclonal Antibody	Inquiry
Echis Venom	DPAB-JX2371338	Sheep Anti-Echis pyramidum Venom Polyclonal Antibody	Inquiry
Crotalus Venom	DPAB-JX2371317	Sheep Anti-Crotalus horridus Venom Polyclonal Antibody	Inquiry

Polyclonal Antibodies Production Process

1. Antigen and Adjuvant Preparation

2. Animal Selection

3. Immunization

Polyclonal Antibodies Production Process

4. Serum Collection

5. Antibody Purification

6. Quality Control

As a specialized manufacturer in this sector, we have an edge over the rest in the low price of antibody manufacturing. Creative Diagnostics offer a complete antibody production solution to international clients, according to the customer's requirements.

Polyclonal Antibody Production

Polyclonal Anti-idiotypic Antibody Production

Polyclonal vs. Monoclonal Antibodies

	Monoclonal Antibodies (mAbs)	Polyclonal Antibodies (pAbs)
Origin	Derived from a single clone of B cells	Produced by multiple B cell clones
Specificity	High specificity for a single epitope	Broad specificity, recognizing multiple epitopes
Production Time	Longer (typically 6+ months)	Shorter (typically 3-4 months)
Cost	Generally higher	Generally lower
Consistency	High batch-to-batch consistency	Variable between batches
Purity	High purity	Lower purity
Applications	Suitable for targeted therapies and diagnostics	Versatile for research, diagnostics, and treatment
Sensitivity	More sensitive in quantification assays	Higher sensitivity due to multiple binding sites
Cross-reactivity	Low cross-reactivity	Higher potential for cross-reactivity

Polyclonal Antibodies for Applications

Disease Diagnosis

ELISA tests for viral infections

Therapeutic Uses

Snake antivenoms for envenomation treatment

Immune Response Modulation

Combining therapeutic cancer vaccines with polyclonal antibodies

Basic Research

Western blotting for protein detection

Cellular Analysis

Flow cytometry to analyze immune cell populations

Protein Localization

IF to visualize protein expression

More Polyclonal Antibodies Resources

Polyclonal vs. Monoclonal Antibodies Protocol

Polyclonal Antibody FAQs

Antibody FAQs

Still have questions?

01What are the advantages of pAb?

Broad Specificity: They can identify several epitopes on an antigen.
Cost-Effective: Usually much faster and cheaper to make than monoclonal antibodies.
High Sensitivity: Their ability to bind multiple sites increases detection sensitivity in assays.

02How are pAbs purified?

It's usually isolated by serum extraction, followed by protein A or G affinity chromatography separation of the target antibodies from the rest of the serum.

03What about the production of pAbs by adjuvants?

Adjuvants are agents in vaccines that bolster the immune system. They enhance a larger antibody response when the antigen is injected into the animal.

04What about selecting a host species for pAb production?

There are immunogenicity, cross-reactivity, easy handling and the amount of serum that can be extracted from the species.

05How do researchers ensure the specificity of pAbs?

Usually, researchers can verify specificity by WB or ELISA, to ensure that the antibody reacts only with the target protein and doesn’t react with other proteins.

Chromatin Immunoprecipitation (ChIP) Protocol

Creative Diagnostics is a "One stop" antibody solutions provider serving the pharmaceutical, biotech, diagnostic and university research organizations around the world.

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