Chloride is the most abundant anion and serves many different biological roles. As a counterion for Na+ and K+, chloride ensures electroneutrality both under steady state and during transport across cellular membranes, as exemplified by transepithelial transport and acidification of intracellular vesicles. Owed to its high concentration, it serves, together with positively charged counterions, as important osmolyte to drive water across cellular membranes in cell volume regulation and transepithelial secretion or absorption of water. Chloride may also have "chemical" roles by binding to proteins and thereby modifying their function.
In mammals, ClC-1, -2, -Ka/-Kb are plasma membrane Cl− channels, whereas ClC-3 through ClC-7 are 2Cl−/H+-exchangers in endolysosomal membranes. Biological roles of CLCs were mostly studied in mammals, but also in plants and model organisms like yeast and Caenorhabditis elegans. CLC Cl− channels have roles in the control of electrical excitability, extra- and intracellular ion homeostasis, and transepithelial transport, whereas anion/proton exchangers influence vesicular ion composition and impinge on endocytosis and lysosomal function.
Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
| Cat. No | Product Name | Reactivity | Application |
| DMABT-H13446 | Anti-CLIC1 monoclonal antibody, clone 3E5 | H | IHC, WB, ELISA |
| DMABT-H13448 | Anti-CLIC1 monoclonal antibody, clone 4G0 | H | IHC, WB, ELISA |
| DPABH-15451 | Anti-CLIC1 (aa 62-111) polyclonal antibody | H | ELISA, WB, IHC-P |
Chloride intracellular channel protein 2 (CLIC2) belongs to the CLIC family of conserved metazoan proteins. Chloride intracellular channel protein 2 can insert into membranes and form chloride ion channels. Channel activity depends on the pH. It is a plasma membrane inwardly rectifying chloride channel functionally significant in airway epithelia and the central nervous system. In epithelia, CLCN2 is apical and has been suggested to play a role in Cl− efflux.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-6133 | Anti-CLIC2 monoclonal antibody, clone FQS7505 | H | ICC/IF, IP, IHC-P, WB |
| CABT-BL4393 | Anti-CLIC2 (aa 109-158) polyclonal antibody | H | WB, ELISA |
Chloride intracellular channel protein 3 is a protein that in humans is encoded by the CLIC3 gene. This protein is a chloride channel. It is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family.
| Cat. No | Product Name | Reactivity | Application |
| CABT-BL1087 | Anti-CLIC3 (aa 1-220) polyclonal antibody | H | IHC-P, WB |
| CABT-BL1085 | Anti-CLIC3 (internal region) polyclonal antibody | H | WB, ELISA |
Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC1261 | Anti-CLIC4 polyclonal antibody | H, M | WB, IF, ELISA |
| DCABH-7529 | Anti-CLIC4 monoclonal antibody, clone FQS25364 | H, M, R | WB, IHC-P, ICC/IF, IP, FC |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; Ch Chicken
References
