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Schistosoma Japonicum Antigens

Schistosoma japonicum is a parasitic flatworm and one of the major infectious agents of schistosomiasis, cause which is a significant human schistosomiasis and occurs in China, Philippines Indonesia and Thailand. S. japonicum is the cause of schistosomiasis japonica, a disease that still remains a significant health problem especially in marshland regions and lake. Schistosomiasis is an infection caused mainly by three schistosome species; Schistosoma mansoni, Schistosoma japonicum and Schistosoma haematobium. Approximately 700,000 people are infected with Schistosoma japonicum in China. As in other parts of the world, schistosomiasis control efforts have focused primarily on the distribution of the antischistosomal drug and praziquantel.

The life cycles of Schistosoma japonicum and Schistosoma mansoni are very similar. The Schistosoma japonicum life cycle involves a snail intermediate host and a definitive host. Adult schistosomes can survive in the human body and a variety of mammalian hepatic portal vein and mesenteric vein system. The female parasites lay eggs in the mesenteric vein capillaries, which drain the small intestine in the definitive host. Eggs are mainly distributed in the liver and colon wall tissue, a small part of the excreted with the host feces. In water, the eggs give rise to miracidia, also called larva. The miracidia then has to infect a snail of the genus Oncomelania such as species of Oncomelania hupensis. Miracidia penetrate into and migrate through snail tissues to develop into sporocysts, which give rise to cercariae. Humans are infected by coming in contact with water contaminated with cercariae, cercariae is actively penetrate into the skin. Parasite transmission requires three factors: surface water, which is contamination with faecal excreta, freshwater snails and human water contact. The life cycle of Schistosoma japonicum is showed in Fig1.

Schistosoma Japonicum Antigens

Fig.1 Life cycle of Schistosoma japonicum

S. japonicum has been identified in over 40 different species of wild and domestic animals, it is a serious cause of morbidity and mortality in some of them, especially in cattle and goats. Creative Diagnostics now can provide high quality recombinant S. japonicum antigens for researchers all over the world. Welcome to contact our customer service to get more information.
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