Growth Cone Markers Antibodies

The growth cone is a highly dynamic, actin-rich structure capable of recognizing and responding to a variety of guidance cues. It consists of two major domains, the peripheral and central domains, which are characterized by specific cytoskeletal components. The peripheral domain is rich in actin filaments, while the central domain mainly contains microtubules, mitochondria, and various other organelles. Neuronal growth cones execute important steps in neural wiring, including axonal growth and pathfinding, and accurate synaptogenesis.

Growth Cone Markers

GAP43

GAP43

Growth-associated protein (GAP-43) is a proven marker for developing and regenerating neurons, and to a lesser extent, reactive glial cells. It is expressed in conditions of embryonic growth, during axonal regeneration, and even at maturity in certain areas of the brain known to exhibit synaptic plasticity and is used widely to specifically label injured neurons and to score neuronal regeneration.

Cat. No	Product Name	Reactivity	Application
DCABH-2243	Anti-GAP43 monoclonal antibody, clone HBQ-9B23	H, M, R	WB, IHC
DCABH-5087	Anti-GAP43 monoclonal antibody, clone TD71-17	H, M, R	WB, ICC/IF, IHC, IP, FC
DPABH-00931	Anti-Human GAP43 polyclonal antibody	H, M, R	WB, IP, IHC, ELISA

See all GAP43 antibodies

Drebrin

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome.

Cat. No	Product Name	Reactivity	Application
DPAB2283GH	Anti-DBN1 (aa 254-272) polyclonal antibody	H	IF, IHC, WB, IP
DCABH-6232	Anti-DBN1 monoclonal antibody, clone FQS23751(C)	H, M, R	IP, WB, ICC/IF
DCABH-6476	Anti-DBN1 monoclonal antibody, clone FQS23745	H, M, R	WB, ICC/IF, IP

See all Drebrin antibodies

SNAP25

Synaptosomal-associated protein-25 (SNAP25) is a presynaptic protein that takes part in vesicular exocytosis, neurite outgrowth, and long-term potentiation.

Cat. No	Product Name	Reactivity	Application
DCABH-319	Anti-SNAP25 monoclonal antibody, clone TQ23	H	IHC-P, ELISA, WB
DPABH-16338	Anti-Human SNAP25 polyclonal antibody	H, M, R	WB, IP, IF, ELISA
DCABH-8228	Anti-SNAP25 monoclonal antibody, clone TNJ 92	M, Ch	WB, ELISA, IHC

See all SNAP25 antibodies

CRMP1

Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that mediates signal transduction of axonal guidance and neuronal migration. It is localized at axons and growth cones, and mediates Sema3A-induced growth cone collapse response in DRG neurons.

Cat. No	Product Name	Reactivity	Application
DCABH-6849	Anti-CRMP1 monoclonal antibody, clone FQS25631(C)	H, M, R	WB, IHC-P
DPABH-16847	Anti-CRMP1 (aa 174-190) polyclonal antibody	H, M, R	WB
DPABH-18413	Anti-CRMP1 (aa 2-51) polyclonal antibody	H	WB, ELISA

See all CRMP1 antibodies

CRMP2

CRMP2 has functions beyond cytoskeletal regulation, including axonal transport, vesicle trafficking, and neurotransmitter release. It is localized at axons and growth cones and enhances the advance of growth cones by regulating microtubule assembly and Numb-mediated endocytosis.

Cat. No	Product Name	Reactivity	Application
DCABH-6849	Anti-CRMP1 monoclonal antibody, clone FQS25631(C)	H, M, R	WB, IHC-P
DPABH-16847	Anti-CRMP1 (aa 174-190) polyclonal antibody	H, M, R	WB
DPABH-18413	Anti-CRMP1 (aa 2-51) polyclonal antibody	H	WB, ELISA

See all CRMP2 antibodies

DCLK1

Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene. DCLK1 is highly expressed during embryogenesis and is localized to neuronal growth cones.

Cat. No	Product Name	Reactivity	Application
DCABH-11227	Anti-DCLK1 monoclonal antibody, clone 7G0	H, M	WB, ELISA
DPABH-27917	Anti-DCLK1 polyclonal antibody	H, M, R	WB, ICC/IF, IHC, IP

See all DCLK1 antibodies

BASP1

Brain acid-soluble protein-1 (BASP1) is highly expressed in the growth cones of nerve cells where it is involved in signal transmission and cytoskeleton organization.

Cat. No	Product Name	Reactivity	Application
CABT-BL4202	Anti-BASP1 (N-terminal) polyclonal antibody	M, R	WB, IHC
CABT-BL4203	Anti-BASP1 (aa 129-159) polyclonal antibody	H, M	WB

See all BASP1 antibodies

Doublecortin/DCX

Doublecortin, or DCX, is considered to be a marker of neurogenesis in the central nervous system. It is expressed by migrating neurons and can be observed at the beginning stages of neuronal development.

Cat. No	Product Name	Reactivity	Application
DCABH-878	Anti-DCX monoclonal antibody, clone 5B4	H	WB, FC, ICC/IF
DPAB-DC551	Anti-DCX (internal region) polyclonal antibody	M	WB, ELISA
CABT-L3486	Anti-Human DCX (Phospho-S415) polyclonal antibody	H, M, R	IHC, ELISA

See all Doublecortin/DCX antibodies

CAP1

Adenylyl cyclase-associated protein 1 is an enzyme involved in the cyclic AMP pathway. CAP1 has been reported as neuronal growth cone associated protein and as regulator of growth cone morphology through rearrangement of F-actin.

Cat. No	Product Name	Reactivity	Application
DPABH-14135	Anti-Human CAP1 polyclonal antibody	H	WB, IHC-P
DCABH-4447	Anti-CAP1 monoclonal antibody, clone FQS9440(C)	H, M, R	WB, IHC-P, FC

See all CAP1 antibodies

Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail

References

Arimura, N. , et al. "Phosphorylation by Rho Kinase Regulates CRMP-2 Activity in Growth Cones." Molecular and Cellular Biology 25.22(2005):9973-9984.
"Regulation of Spine Development by Semaphorin3A through Cyclin-Dependent Kinase 5 Phosphorylation of Collapsin Response Mediator Protein 1. " Journal of Neuroscience 27.46(2007):12546-12554.

Neuroscience Antibodies