The presynaptic terminal, often referred to as the axonal terminal, releases neurotransmitters into the synaptic cleft in order to deliver signals to the postsynaptic neuron. In the cytoplasm of the presynaptic membrane, there are many synaptic vesicles, some microfilaments and microtubules, mitochondria and slippery endoplasmic reticulum, etc.Synaptic vesicles are characteristic structures at the front of the synapse that contain chemicals called neurotransmitters.
Synaptosomal-associated protein-25 (SNAP25) is a presynaptic protein that takes part in vesicular exocytosis, neurite outgrowth, and long-term potentiation.
| Cat. No | Product Name | Reactivity | Application |
| DCABH-319 | Anti-SNAP25 monoclonal antibody, clone TQ23 | H | IHC-P, ELISA, WB |
| DPABH-16338 | Anti-Human SNAP25 polyclonal antibody | H, M, R | WB, IP, IF, ELISA |
| DCABH-8228 | Anti-SNAP25 monoclonal antibody, clone TNJ 92 | M, Ch | WB, ELISA, IHC |
Syntaxins are a family of membrane proteins primarily localized to the plasma membrane of the presynaptic active zone, of which syntaxin-1 is the primary form involved in vesicle fusion.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC2990 | Anti-STX1A (N-terminal) polyclonal antibody | M | WB, ELISA |
| DPABH-08356 | Anti-Human STX1A polyclonal antibody | H | WB, IHC |
| DCABH-5465 | Anti-STX1A monoclonal antibody, clone FQS22184(C) | H, M, R | WB, IP |
The SV protein 2A (SV2A) is an integral 12-transmembrane domain glycoprotein expressed in synaptic vesicles throughout the brain. This protein can bind two adenine molecules and possibly links cellular energy state to vesicle release.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC3918 | Anti-SV2A (aa 474-530) polyclonal antibody | H | WB, ELISA |
| DPABH-17758 | Anti-SV2A (aa 1-100) polyclonal antibody | H, M, R | IHC, WB, ICC/IF, IP |
Synaptophysin is an integral membrane glycoprotein (Mr 38,000) that occurs in presynaptic vesicles of neurons and in similar vesicles of the adrenal medulla.
| Cat. No | Product Name | Reactivity | Application |
| DMAB5564RH | Anti-SYP monoclonal antibody, clone TK37-96 | H, M, R | WB, IHC, ICC/IF |
| CABT-50984MS | Anti-SYP monoclonal antibody, clone SY38 | H, M, R, B | WB, IHC |
| DPABH-28508 | Anti-Human SYP polyclonal antibody | H | WB, IHC |
Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles. Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin. Because of Synapsin 1's characteristic sub-cellular localization, antibodies against this protein have been used as one of the most reliable markers for pre-synaptic vesicles.
| Cat. No | Product Name | Reactivity | Application |
| CPBT-66681RB | Anti-SYN1 (native protein) polyclonal antibody | H, M, R, B | WB, IHC, IF, IP |
| CABT-B1484 | Anti-SYN1 monoclonal antibody, clone NFHT4-20B | M | WB, ICC |
| CABT-L4139 | Anti-Human SYN1 (Phospho-Ser553) polyclonal antibody | H, M, R | IHC, IF, ELISA |
Synaptotagmin 1 is a 47,442 dalton protein (422 amino acids) associated with pre-synaptic terminals of the PNS and CNS. Synaptotagmin-1 binds calcium and initiates the fusion of vesicles with the pre-synaptic membrane. This protein also is believed to be the target of proteolytic activity associated with Botulinum neurotoxin A.
| Cat. No | Product Name | Reactivity | Application |
| DPAB-DC3004 | Anti-SYT1 (internal region) polyclonal antibody | H | WB, IHC-P, ELISA |
| DPABH-25191 | Anti-SYT1 (aa 307-311) polyclonal antibody | H, M, R | WB, ICC/IF |
| DPABH-25444 | Anti-SYT1 polyclonal antibody | H, M, R | WB, IHC-P, ICC/IF |
Species: H Human; M Mouse; R Rat; Z Zebrafish; X Xenopus laevis; B Bovine; C Cow; D Dog; P Pig; Q Quail; G Goat; Ch Chicken
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