Schwann Cell Marker Antibodies

Oct6/POU3F1

Oct6 is present in cytoplasm of Schwann cells associated with normal-appearing myelinated nerve fibers, but not in nuclei. Expression is seen in nuclei of Schwann cells in the early phase of acute axonal degeneration; nuclear expression peaks at the regenerative stage.

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Krox20/EGR2

EGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells.

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MBP

Myelin basic protein (MBP) is a major myelin constituent produced by oligodendrocytes in the central nervous system (CNS). Expression of MBP was considered to be a marker for oligodendrocyte differentiation and myelination in the developing CNS and it has long been considered as a marker of active demyelination.

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MPZ

Myelin protein zero (P0, MPZ) is a single membrane glycoprotein, which is a major structural component of the myelin sheath in the peripheral nervous system (PNS). Myelin protein zero is expressed by Schwann cells and accounts for over 50% of all proteins in the peripheral nervous system, making it the most common protein expressed in the PNS.

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NCAM1

NCAM is a differentiation marker of postmigratory immature neurons in the developing human nervous system. NCAM was expressed by non-myelinating Schwann cells from normal nerves and over-expressed by Schwann cells from patients with chronic axonal neuropathies and Schwannomas.

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SOX10

Sox proteins are characterized by possession of a DNA-binding domain with similarity to the high-mobility group domain of the sex determining factor SRY. During development Sox10 first appeared in the forming neural crest and continued to be expressed as these cells contributed to the forming PNS and finally differentiated into Schwann cells. In the CNS, Sox10 transcripts were originally confined to glial precursors and later detected in oligodendrocytes of the adult brain.

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S100B

S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B has emerged as a candidate peripheral biomarker of blood–brain barrier (BBB) permeability and CNS injury.

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P75NTR

Nerve growth factor receptor p75NTR is a major neurotrophin receptor involved in manifold and pleiotropic functions in the developing and adult central nervous system (CNS). Depending on the complex interactions with other receptors and on the cellular context, p75NTR is capable of performing contradictory tasks such as mediating cell death as well as cell survival. In parallel, as a prototype marker for certain differentiation stages of Schwann cells and related CNS aldynoglial cells, p75NTR has recently gained increasing notice as a marker for cells with proposed regenerative potential in CNS diseases, such as demyelinating disease and traumatic CNS injury.

SOX2

SOX2, a HMG box transcription factor, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. SOX2 belongs to the family of SOXB1 factors and is a pivotal regulator of maintenance and induction of both PSCs and neural progenitor cells.

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