Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Recombinant protein within human gephyrin
Applications
Application Notes
ICC/IF: 1/50 - 1/100; IHC-P: 1/100 - 1/250; WB: 1/1000 - 1/5000.
Target
Alternative Names
GPHN; gephyrin; KIAA1385; GPH; GEPH; GPHRYN;
Product Background
Antigen Description
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Pathway
GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Molybdenum cofactor biosynthesis, organism-specific biosystem; molybdenum cofactor biosynthesis, conserved biosystem;
Citations
Publication ()
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COA
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