Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Recombinant fragment within Human Homer aa 100-250. The exact sequence is proprietary.Database link: Q86YM7
Applications
Application Notes
IP: 1/60 - 1/80; WB: 1/1000 - 1/10000; IHC-P: 1/500.
Target
Alternative Names
HOMER1; homer homolog 1 (Drosophila); homer protein homolog 1; HOMER 1B; SYN47; Ves 1; homer-1; homer, neuronal immediate early gene, 1; HOMER; Ves-1; HOMER1A; HOMER1B; HOMER1C;
Product Background
Antigen Description
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Pathway
Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem.
Citations
Publication ()
Have you cited DCABH-7937 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
