Anti-GABBR2 monoclonal antibody, clone 6H8G8

Antibody Isotype

IgG2a

Clone

6H8G8

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human GABA B Receptor 2 aa 319-383 (internal sequence). Expressed in E. Coli.Sequence: FEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKT LQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFR NGERMGTIKFTQFQDSREVKVGEYNAVA

Conjugate

Application Notes

IHC-P: 1/200 - 1/1000; WB: 1/500 - 1/2000; ICC/IF: 1/200 - 1/1000.

Alternative Names

GABBR2; gamma-aminobutyric acid (GABA) B receptor, 2; G protein coupled receptor 51 , GPR51; gamma-aminobutyric acid type B receptor subunit 2; GABABR2; GPRC3B; HG20; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coup

Entrez Gene ID

UniProt ID

Antigen Description

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Pathway

Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem;