Rabbit Anti-Human TPCN2 (N-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

raised was raised against a peptide from N terminal residues of human TPCN2 protein

Conjugate

General Notes

This product (Catalog No. DPABH-14039) is a rabbit-derived polyclonal antibody raised against human TPCN2. This antibody exhibits cross-reactivity with TPCN2 from mouse and rat. It has been affinity purified by Protein A. TPCN2 (two pore segment channel 2) is a protein-coding gene in humans that encodes TPC2, a cation-selective ion channel protein with two repeats of a six-transmembrane domain, localized primarily to the membranes of lysosomes and late endosomes. This channel functions as an intracellular calcium-release mechanism, regulating organellar membrane excitability, endolysosomal trafficking, pH homeostasis, and degradation pathways critical for cellular processes such as pigmentation and lipid metabolism. Mutations in TPCN2 are associated with variation in skin, hair, and eye pigmentation, including skin/hair/eye pigmentation variation 10 (SHEP10) and, more recently, a novel autosomal dominant form of hypopigmentation with ocular features, highlighting its role in melanosome function and melanin synthesis. Additionally, TPCN2 influences broader physiological processes, such as susceptibility to non-alcoholic fatty liver disease through its impact on endolysosomal lipid handling.
DPABH-14039 is suitable for use in ELISA, Western blot (WB), IHC applications.
DPABH-14039 is supplied as a liquid formulation in PBS, pH 7.4 with 0.02% Sodium Azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

TPCN2; two pore segment channel 2