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Double-stranded RNA (dsRNA) is a viral product, which is produced by positive-strand RNA viruses, dsRNA viruses, and DNA viruses. However, negative-strand RNA viruses are not shown to generate any significant dsRNA signals (1). Creative Diagnostics offers a range of anti-double-stranded RNA monoclonal antibodies, which can be used for the in Vitro detection of the dsRNA intermediates of various RNA viruses and diagnosis research, also can contribute to the RNAi research (2) and could potentially be used in gene therapy (3).

Complement component 5 (C5) is a protein from the complement system playing an important role in inflammatory and cell killing process. C5a as a cell signaling protein can initiate an adaptive immune response and release cytokines with its ligand, C5a receptor (C5aR). The over-activation of C5a anaphylatoxin with C5aR can cause cytokine storm, endothelial inflammation and thrombosis in severe forms of COVID-19. Creative Diagnostics now provides a broad range of well-validated antibodies, antigens as well as research grade biosimilars with abundant quality control data in comprehensive applications.

It was not long after the discovery of immune checkpoints (IC) that it was shown that cancer cells evolve to express more inhibitory immune checkpoint molecules to help them evade the immune system.

The number of measles cases worldwide surged to nearly 900,000 in 2019, and the deaths climb 50% from 2016 to 2019. To address the current measles crisis, over 95% of the world's population must be vaccinated with the required two doses of measles-containing vaccines (MCV). Detection of measles-specific IgM antibody in serum is the most common laboratory test. Creative Diagnostics has a series of measles virus antigens suitable for both IgM and IgG detection.

Creative Diagnostics has launched 4 new recombinant proteins for diagnosis of arthropod-borne diseases, including Severe fever with thrombocytopenia syndrome virus (SFTSV), Rift valley fever virus (RVFV), Coxiella burnetii, and Orientia tsutsugamushi. Creative Diagnostic’s range of high purity recombinant antigens of arthropod-borne pathogen are ideal for developing quantitative antibody tests. They are produced in E. coli system which can ensure lot-to-lot consistency.

Epstein-Barr Virus (EBV) is one of the most prevalent human viruses, as it affects more than 90% of adults in the world. Blood tests for EBV detect antibodies against EBV in the blood and help establish a diagnosis of EBV infection. Creative Diagnostics offers recombinant antigens p18 and p23 (Viral capsid antigens, VCA), p54 and p138 (Early antigens, EA) and EBNA1 (Nuclear antigen, EBNA). These recombinant antigens in immunoassays are suitable for the detection of IgG and IgM antibodies against EBV in blood samples.

Respiratory syncytial virus (RSV) is a very contagious virus that causes a respiratory tract infection, affecting 64 million people per year worldwide. Currently, there is no licensed vaccine to prevent RSV infections. The only FDA approved treatment option is a humanized monoclonal antibody (IgG) against the RSV fusion protein, known as palivizumab. Creative Diagnostics has released a range of RSV recombinant antigens and antibodies. All of them are produced using a standardized production process to ensure the highest quality. These reagents can assist your research for RSV vaccine development.

Our range of vaccine R&D reagents include more than 40 native antigens of key infectious pathogens, including Corynebacterium diphtheriae, Clostridium tetani, Enterovirus, Hepatitis virus, Influenza virus, Poliovirus, Rotavirus, Streptococcus pneumoniae, and Zika virus. These antigens can be used in a variety of applications, from the development of conjugate vaccines, to the evaluation of vaccination efficacy by antibody tests.

The three main classes of sex hormones are androgens, estrogens and progestogens, which play important roles in various physiological processes.

Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes acute encephalitis along with high mortality rates (40-75%). Therefore, there is an urgent need for effective NiV vaccines and therapeutics.

Creative Diagnostics has developed a range of native and recombinant staphylococcal enterotoxin antigens. These antigens are well-validated in double-antibody sandwich enzyme-linked immunosorbent assay (ELISA).

Streptococcus pneumoniae is a significant human pathogenic bacterium that causes pneumococcal disease. The two main modes of preventing pneumococcal infections are using antibiotics and vaccinations against pneumococcus.

Human papillomavirus (HPV) is a virus from the papillomavirus family that is capable of infecting humans. There are nearly 200 different strains of HPV, most of which are harmless and not cancer causing.

Diphtheria, tetanus, pertussis and haemophilus influenzae type b are four infectious diseases that are particularly dangerous to babies. Vaccines are the best way to protect against these infectious diseases.

Hirudin prevents or dissolves the formation of clots and thrombi, and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins. Recombinant hirudin (r-hirudin or lepirudin) not only provides effective anticoagulation in patients with heparin-induced thrombocytopenia (HIT) but also allows rapid platelet recovery.

Tuberculosis (TB) is a contagious and often severe airborne disease caused by infection with Mycobacterium tuberculosis bacteria. TB usually affects the lungs, but can also affect other parts of the body.

Compared to traditional indirect assays, the double-antigen sandwich ELISA displays higher specificity and better sensitivity. With years of experience in production of proteins and antigens, Creative Diagnostics now can provide our customers matched antigen pairs of HCV with high-quality and cheaper price for the development of double-antigen sandwich ELISA.

Helicobacter pylori (H. pylori), a powerful carcinogenic pathogen, is responsible for the induction of 75% of gastric cancers worldwide. In general, the current treatment for patients who are infected with H. pylori consists of daily administration of three antibiotics, proton pump inhibitor, amoxicillin, clarithromycin.

The Omicron variant, with a large number of spike gene mutations was designated a variant of concern (VOC). There is still considerable uncertainty related to the transmissibility, vaccine effectiveness, severity of infection and other properties of the Omicron variant.

Viruses are infectious pathogens that cause a broad range of diseases. They are small particles, typically between 20 and 300 nanometers in length, containing RNA or DNA. Viruses require a host cell to replicate.

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