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Nov 16-19, 2026 - Düsseldorf, Germany
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July 26-30, 2026 – Anaheim, CA, USA
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    3. Anti-Human CTLA-4 (Ipilimumab) monoclonal antibody, Functional Grade

    Anti-Human CTLA-4 (Ipilimumab) monoclonal antibody, Functional Grade Functional Grade

    Human anti-Human CTLA-4 (Ipilimumab) monoclonal antibody for FA

    Low Endotoxin/Azide Free CTLA4 antibody available!

    pdf COA pdf SDS pdf Datasheet
    Specifications
    Antibody Isotype
    IgG1, κ
    Clone
    MDX-010
    Species Reactivity
    Human
    Immunogen
    Human CTLA-4
    Conjugate
    Functional Grade
    Images
    Functional assay. (B) ADCC activity of various anti-CTLA-4 mAbs against human CTLA-4-expressing CHO cells. (C) ADCC activity to each cellular fraction of CD4+ and CD8+ T cells from PBMCs by ART-Fc, IgG1, or silent-Fc anti-CTLA-4 mAbs.
    Neutralization. CHO cells stably expressing human CTLA-4 were treated with either control human IgG or Ipilimumab (Ipi), then the CTLA-4 protein levels were analyzed by western blot. Cell surface CTLA-4 on CHO cells used in (a) was measured by ?ow cytometry.
    Impairs effector CD4+ T cell responses
    Scatter plots showing cytokine concentrations in the TT-stimulated cultures in the presence of different CTLA-4 antibodies.
    Target
    Alternative Names
    CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; CD 152; CD152
    Entrez Gene ID
    1493
    UniProt ID
    P16410
    Citations
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    Customer Reviews
    Ribas, A; Glaspy, JA; et al. Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy. JOURNAL OF IMMUNOTHERAPY 27:354-367(2004).
    Daniel, V; Sadeghi, M; et al. In-vitro inhibition of IFN gamma(+) iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function. BMC IMMUNOLOGY 13:-(2012).
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