Specifications
Immunogen
The details of the immunogen for this antibody are not available.
Applications
Application Notes
Flow Cyt: 3μg/106 cells.
Target
Alternative Names
CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4; Cd152; Ly-56; Ctla-4;
Product Background
Antigen Description
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Pathway
Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem;
Citations
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Aranda, F; Vacchelli, E; et al. Immunostimulatory monoclonal antibodies in cancer therapy. ONCOIMMUNOLOGY 3:-(2014).
Abbasian, J; Mahmud, D; et al. Allogeneic T cells induce rapid CD34(+) cell differentiation into CD11c(+)CD86(+) cells with direct and indirect antigen-presenting function. BLOOD 108:203-208(2006).
COA
Certificate of Analysis
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