Anti-CTLA4 monoclonal antibody, clone COJ4

Antibody Isotype

IgG2a

Clone

COJ4

Species Reactivity

Human

Immunogen

Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig).

Conjugate

Application Notes

ICC: 5 - 50 μg/ml; Flow Cyt: 2μg/5x 10⁵ cells; IHC-Fr: 5 - 50 μg/ml;

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; CD 152; CD; CD152; CD152 antigen; Celiac disease 3; CELIAC3; CTLA 4; CTLA-4; CTLA4; CTLA4_HUMAN; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cyto

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Pathway

Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune Syst