Anti-Human CTLA-4 monoclonal antibody (CABT-L2927)

Specifications


Host Species
Mouse
Antibody Isotype
IgG
Clone
JID115
Species Reactivity
Human
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: IHC: 1:100 - 1:200
Positive and negative controls should be simultaneously run with unknown specimens, as there are no conclusive characteristics to suggest instability of the antibody.
The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.
The concentrated antibody requires dilution in the optimized buffer, to the recommended working dilution range (as above).
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


CTLA-4 Mouse Mab on Tonsil

Target


Alternative Names
CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5
Entrez Gene ID
UniProt ID

Product Background


Pathway
Adaptive Immune System; Autoimmune thyroid disease; CTLA4 inhibitory signaling; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Immune System; Rheumatoid arthritis;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Snanoudj, R; de Preneuf, H; et al. Costimulation blockade and its possible future use in clinical transplantation. TRANSPLANT INTERNATIONAL 19:693-704(2006).
Esper, P; et al. Immune Modulation in Melanoma and Advanced Cancer Therapy: Anti-Cytotoxic T Lymphocyte-Associated Antigen 4 Monoclonal Antibodies. CLINICAL JOURNAL OF ONCOLOGY NURSING 13:547-554(2009).

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