Anti-CTLA4 (aa 36-135) polyclonal antibody

Species Reactivity

Human

Immunogen

CTLA4 (NP_005205, 36 a.a. ~ 135 a.a) partial recombinant protein with GST tag. The sequence is KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNEL TFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMY

Conjugate

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; insulin-dependent diabetes mellitus 12; cytotoxic T-lym

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Pathway

Adaptive Immune System; Autoimmune thyroid disease; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Cell adhesion molecules (CAMs)