The CTLA-4 mAb clone 9H10 antibody recognizes cytotoxic T lymphocyte antigen-4 (CTLA-4) also known as CD152. Antibody 9H10 has shown specific reactivity against CTLA-4 Ig but not CD4 lg, as well as the ability to block CTLA-4 Ig by binding to B7 transfected cells. Staining of activated T cells, but not freshly isolated T cells, is reported, as well as the ability to stain a CTLA-4 transfectant but not control transfectants. The CTLA-4 mAb (9H10) antibody has shown effectiveness in reducing tumor growth and metastasis in preclinical models. These characteristics make the 9H10 antibody a reliable tool for identifying and studying CTLA-4 in various immunological contexts.
Target
Alternative Names
CTLA-4
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