Anti-CTLA4 monoclonal antibody, clone 3G2

Antibody Isotype

IgG2a

Clone

3G2

Species Reactivity

Human

Immunogen

CTLA4 (NP_005205, 36 a.a. ~ 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

cytotoxic T-lymphocyte-associated protein 4; GRD4; CD152; IDDM12; CD; CD28; GSE; OTTHUMP00000216623; ICOS; cytotoxic T-lymphocyte antigen 4; celiac disease 3; cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymph

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Mouse monoclonal antibody raised against a partial recombinant CTLA4.

Pathway

Adaptive Immunity Signaling, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem