Mouse Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

Product Overview

Amino Acid Sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTK EQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDP GSEAYEMPSE EGYQDYEPEA

Nature

Recombinant

Tag/Conjugate

Unconjugated

Alternative Names

Alpha synuclein PFFs; Alpha synuclein PFF; Alpha synuclein aggregates; Alpha synuclein protein aggregates; Active Alpha synuclein aggregates; Alpha-synuclein protein; Non-A beta component of AD amyloid protein; Non-A4 component of amyloid precursor protein; NACP protein; SNCA protein; NACP protein; PARK1 protein; SYN protein; Parkinson's disease familial 1 Protein

Purity

≥95%

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

PBS, pH 7.4

Preservative

None

Storage

Store at -80°C

Introduction

Alpha-synuclein (αSyn) is a soluble presynaptic localization protein used in conjunction with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and the chaperone protein cysteine string protein α (CSPα) to facilitate vesicle pool repopulation and vesicle release from the active zone.
Under pathological conditions, this soluble protein undergoes multiple post-translational modifications and forms higher-order oligomers and fibrillar species, resulting in conformationally and biologically distinct inclusions.
These inclusions are known as Lewy bodies (LB) and Lewy neuropils (LN) in Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB), or glial cytoplasmic inclusions (GCI) in multiple system atrophy. In addition, neurodegenerative diseases with αSyn pathology are known as synucleinopathies.

Entrez Gene ID

20617

Keywords

Alzheimer's Disease; Neurodegeneration; Neuroscience; Parkinson's Disease; Synuclein; Tangles & Tau