Anti-SNCA monoclonal antibody, clone Tzo625

Antibody Isotype

IgG

Clone

Tzo625

Species Reactivity

Human

Immunogen

Full length protein (Human): oxidized alpha synuclein.

Conjugate

Application Notes

WB: 1/500;

Alternative Names

SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4,Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1; Alpha synuclein; Alpha-synuclein; Alpha-synuclein, isoform NACP140; alphaSYN; MG

Entrez Gene ID

UniProt ID

Antigen Description

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Pathway

Alpha-synuclein signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Parkinsons disease, organism-specific biosystem;