Alpha Synuclein Preformed Fibrils (Type 2)

Product Overview

Amino Acid Sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEG VVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGF VKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSE

Nature

Recombinant

Tag/Conjugate

Unconjugated

Bio-activity

Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out.

Alternative Names

Alpha synuclein PFFs; Alpha synuclein PFF; Alpha synuclein aggregates; Alpha synuclein protein aggregates; Alpha synuclein aggregates; Alpha-synuclein protein; Non-A beta component of AD amyloid protein; Non-A4 component of amyloid precursor protein; NACP protein; SNCA protein; NACP protein; PARK1 protein; SYN protein; Parkinson disease familial 1 Protein

Purity

≥95%

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

PBS, pH 7.4

Preservative

None

Storage

Store at -80°C

Introduction

Alpha-synuclein (αSyn) is a soluble presynaptic localization protein used in conjunction with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and the chaperone protein cysteine string protein α (CSPα) to facilitate vesicle pool repopulation and vesicle release from the active zone.
Under pathological conditions, this soluble protein undergoes multiple post-translational modifications and forms higher-order oligomers and fibrillar species, resulting in conformationally and biologically distinct inclusions.
These inclusions are known as Lewy bodies (LB) and Lewy neuropils (LN) in Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB), or glial cytoplasmic inclusions (GCI) in multiple system atrophy. In addition, neurodegenerative diseases with αSyn pathology are known as synucleinopathies.

Entrez Gene ID

6622

Keywords

Alzheimer's Disease; Neurodegeneration; Neuroscience; Parkinson's Disease; Synuclein; Tangles & Tau