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HPV Types

Human papillomavirus (HPV) is a highly prevalent sexually transmitted infection, affecting millions of individuals in the United States. It is primarily transmitted through skin-to-skin sexual contact. While many people with HPV may not experience symptoms, the virus can lead to complications such as genital warts. These warts can vary in size, appearance, and location, often appearing on the vulva in women and the penis in men. Additionally, some HPV infections can persist in the body and increase the risk of developing certain types of cancer.

HPV is responsible for:

  • 25% of vulvar cancers
  • 50% of penile cancers
  • 60% of oropharyngeal cancers
  • 78% of vaginal cancers
  • 90% of anal cancers
  • Almost all cases of genital warts and cervical cancer

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Relative sensitivities of nucleic acid analysis techniques.Figure 1. Natural history of oncogenic HPV infection.
(Source: Della Fera, A. N. et al., 2021)

HPV Types

Over 200 types of HPV have been described. These types are classified into high-risk and low-risk categories based on their association with cancer development. High-risk HPV types, such as HPV-16 and HPV-18, are responsible for the majority of HPV-related cancers, including cervical, anal, vaginal, vulvar, penile, and oropharyngeal cancers. These cancers all involve sexually transmitted HPV infection into the stratified epithelial tissue. Low-risk HPV types, such as HPV-6 and HPV-11, are primarily associated with benign conditions like genital warts.

Common symptoms of HPV infection include:

DiseaseRelated HPV type
Common wartsHPV 2, HPV 7, HPV 22
Plantar wartsHPV 1, HPV 2, HPV 4, HPV 63
Flat wartsHPV 3, HPV 10, HPV 28
Anogenital wartsHPV 6, HPV 11, HPV 42, HPV 44 and others
Epidermodysplasia verruciformis (EV)HPV 2, HPV 3, HPV 5, HPV 8, HPV 9, HPV 10, and others
Conjunctival papillomasHPV 6, HPV 11
Focal epithelial hyperplasia (mouth)HPV 13, HPV 32
Laryngeal papillomatosisHPV 6, HPV 11
Mouth papillomasHPV 6, HPV 7, HPV 11, HPV-16, HPV 32
Verrucous cystHPV 60
Oropharyngeal cancerHPV-16
Condylomata acuminataHPV 6, HPV 11, HPV 30, HPV 42, HPV 43, and others
Genital cancersHighest risk: HPV-16, HPV-18, HPV-31, HPV-45
Other high-risk: HPV-33, HPV 35, HPV 39, HPV 51, HPV-52, HPV 56, HPV-58, HPV 59, HPV 66, HPV 68
Probably high-risk: HPV 26, HPV 53, HPV 73, HPV 82

Learn more about HPV Antigens

Low-Risk HPV

Low-risk HPV types are primarily associated with the development of benign conditions, such as genital warts, which can appear on various areas of the body such as the vulva, penis, cervix, vagina, scrotum, anus, mouth, and throat. Genital warts are primarily caused by two HPV strains, types 6 and 11, which account for approximately 90% of cases. Only a small percentage (~1%) of sexually active individuals in the United States experience noticeable genital warts. It is important to treat these warts to prevent their spread to other genital areas and sexual partners. In addition, some strains can cause mild cervical dysplasia, which refers to abnormal changes in the surface cells of the cervix.

Although low-risk types do not typically lead to cancer, they can still cause physical discomfort and psychological distress. Proper diagnosis and management of low-risk HPV infections are crucial to alleviate symptoms and prevent transmission.

High-Risk HPV

Certain types of HPV are classified as "high-risk" because they have the potential to cause cancer. These high-risk HPV types are of particular concern to doctors due to their association with cell changes and pre-cancers that have a higher likelihood of progressing into cancer over time. Out of the at least 12 high-risk strains, HPV types 16 and 18 are responsible for the majority of HPV-related cancers, including those affecting the cervix, vagina, vulva, penis, and anus. Additionally, high-risk HPV strains can also result in oropharyngeal cancer, which affects the throat, tongue, and tonsils.

Learn more about Recombinant HPV 16 and 18 Antigens

Researchers believe that oral sexual contact with an individual who has an active high-risk HPV infection may lead to HPV infections of the mouth and throat. However, it's important to note that for most people, the immune system eliminates HPV infections within two years. While high-risk HPV strains have the potential to cause cancer, most individuals infected with these strains do not develop cancer.

Creative Diagnostics: Your Reliable Partners

HPV typing is a crucial component of HPV-related disease management, prevention, and research. The identification and classification of HPV types enable targeted interventions, such as vaccination and screening programs, to reduce the burden of HPV-related cancers and other conditions. Creative Diagnostics, a trusted company in the field, offers advanced HPV typing solutions that empower healthcare professionals in their efforts to combat HPV. By leveraging our innovative assays and products, clinicians and researchers can make informed decisions, improve patient outcomes, and contribute to the global fight against HPV-related diseases.

References

  1. Della Fera A N, et al. Persistent human papillomavirus infection. Viruses. 2021, 13(2): 321.
  2. Menzo S, et al. Human papillomavirus infections: new perspectives for prevention and treatment. Microbiologica-Quarterly Journal of Microbiological Sciences. 2007, 30(3): 189-212.

HPV Antibodies

HPV Antigens

TargetCat. No.Product NameExpression SystemTag/ConjugateApplication
HPVPSVG-HPV16Pseudotyped GFP HPV16Useful for studying papillomavirus assembly, entry, and neutralization.Inquiry
PSVG-HPV18Pseudotyped GFP HPV18Useful for studying papillomavirus assembly, entry, and neutralization.Inquiry
PSVG-HPV31Pseudotyped GFP HPV31Useful for studying papillomavirus assembly, entry, and neutralization.Inquiry
PSVG-HPV33Pseudotyped GFP HPV33Useful for studying papillomavirus assembly, entry, and neutralization.Inquiry
PSVG-HPV39Pseudotyped GFP HPV39Useful for studying papillomavirus assembly, entry, and neutralization.Inquiry
PSVG-HPV45Pseudotyped GFP HPV45Useful for studying papillomavirus assembly, entry, and neutralization.Inquiry
HPV 11DAGF-228Recombinant Human Papilloma Virus type 11 L1 protein (VLP)E. coliUnconjugatedInquiry
DAG1576Recombinant HPV type 11 [GST]E. coliGSTN/AInquiry
HPV 35DAGC142Recombinant Human Papilloma Virus type 35 L1 protein (VLP)E. coliUnconjugatedSDS-PAGEInquiry
HPV 39DAGC143Recombinant Human Papilloma Virus type 39 L1 protein (VLP)E. coliUnconjugatedSDS-PAGEInquiry
HPV16DAGF-094Recombinant HPV16 E6 protein [His]E. coliHisInquiry
DAGF-095Recombinant HPV16 E6 protein (aa 1-158) [His]YeastHisInquiry
DAGF-096Recombinant HPV16 E7 protein (aa 1-98) [GST]E. coliGSTInquiry
DAGF-229Recombinant Human Papilloma Virus type 16 L1 protein (VLP)E. coliUnconjugatedInquiry
DAG-P2512Recombinant HPV type 16 (aa 1 - 531)E. coliUnconjugatedSDS-PAGEInquiry

More HPV Antigens

HPV ELISA Kits

TargetCat. No.Product NameSizeSpecies ReactivityApplicationDetection Sample
HPVDEIA-F678SHuman Papilloma Virus IgG ELISA kit96THumanQualitativeplasma, serumInquiry
DEIASL404Human HPV18 IgM ELISA kit96TQualitativeSerum, plasmaInquiry
DEIASL405Human HPV 16 L1-capsids IgG ELISA Kit96TQualitativeSerum, plasmaInquiry
DEIASL406Human HPV 16 IgM ELISA Kit96TQualitativeSerum, plasmaInquiry
DEIASL407Human Papilloma Virus IgM ELISA Kit96TQualitativeSerum, plasmaInquiry
DEIASL408Human HPV 18 L1-capsids IgG ELISA Kit96TQualitativeSerum, plasmaInquiry
DEIASL409Rabbit HPV 16 L1-capsids IgG ELISA Kit96TQualitativeSerum, plasmaInquiry
DEIASL410Human high risk HPV L1-capsids (HR-HPVL1) IgG ELISA kit96TQualitativeSerum, plasmaInquiry
DEIASL119HPV(18) Antigen ELISA Quantitation Kit96TQuantitativeSerum, plasmaInquiry
DEIASL120HPV(52) Antigen ELISA Quantitation Kit96TQuantitativeSerum, plasmaInquiry
DEIASL121HPV(58) Antigen ELISA Quantitation Kit96TQuantitativeSerum, plasmaInquiry
DEIASL171Human HPV 16 E7 Oncoprotein ELISA Kit96THumanQuantitativeCell lysates, tissue lysates, cervical smears, plasma, serumInquiry
DEIASL172Human HPV 18 E7 Oncoprotein ELISA Kit96TQuantitativeCell lysates, tissue lysates, or cervical smearsInquiry
HPV16DEIASL118HPV (16) Antigen ELISA Quantitation Kit96THumanQuantitativeSerum and plasmaInquiry
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