Alternative Names
Double stranded deoxyribonucleic acid; Double stranded DNA; dsDNA
Concentration
Batch dependent - please inquire should you have specific requirements.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Antigen Description
dsDNA (double stranded deoxyribonucleic acid) is the genetic material of all cells and many viruses and is a polymer of nucleotides. The monomer consists of phosphorylated 2-deoxyribose N-glycosidically linked to one of four bases, adenine, cytosine, guanine or thymine. These are linked together by 3',5'-phosphodiester bridges. In the Watson-Crick double-helix model, two complementary strands are wound in a right-handed helix and held together by hydrogen bonds between complementary base pairs.
Keywords
dsDNA; double-stranded DNA; SLE; Lupus nephritis
Citations
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Q & A
Q: Is the molecule plasmid DNA?
What about the lenght of the molecule?
A: Regarding the dsDNA-BSA product:
The DNA is linear DNA (not plasmid DNA)
The original dsDNA length is 2857bp.
Customer Reviews
Li, X; Wang, D; et al. Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus. BONE MARROW TRANSPLANTATION 48:544-550(2013).
Shimp, SK; Chafin, CB; et al. Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. CELLULAR & MOLECULAR IMMUNOLOGY 9:255-266(2012).