General Notes
This product (Catalog No. CABT-CSY2603) is a chicken-derived polyclonal antibody raised against fadv Avian Adenovirus Type 5. This antibody exhibits cross-reactivity with Avian Adenovirus Type 5 from fadv-5. Avian adenoviruses are double-stranded DNA viruses containing 30–10 genes. These viruses can be loosely divided into three groups based on antigenic relationships of internal proteins, although the three groups have not been officially recognized by the ICTV. The avian group I adenoviruses include at least 12 serologically distinct types, all of which have been isolated from mildly or asymptomatic poultry. The type species is known as the CELO (chick embryo lethal orphan), or Phelps strain, or F1 (fowl) strain. There are also numerous isolates from other avian species plus electron microscopy and immunological evidence that the type I aviadenoviruses are widely distributed in birds. By themselves, these viruses present no particular clinical problems in commercial poultry, but they are thought to cause significant problems in mixed infections with immunosuppressive viruses such as IBDV and chick infectious anemia virus (CIAV). A virus virtually indistinguishable from the CELO strain known as quail bronchitis virus (QBV) can be devastating in commercial quail operations, causing as high as 80% mortality. Virus isolations and significant antibody levels in wild quail suggest that the virus may present disease problems in nature, although there are no documented cases or epizootics. The group II aviadenoviruses include turkey hemorrhagic enteritis virus (HEV), pheasant marble spleen disease virus (MSDV), and the avian adenovirus splenomegaly (AAS) of chickens. These three agents are serologically indistinguishable but induce differing clinical manifestations in the different species. Infections caused by this virus group appear to target lymphoid tissue, often resulting in immunosuppression, and there are strain-specific differences in virulence among the various group II isolates. HEV reached epidemic proportions in the 1960s and still causes significant problems in turkey-producing states in the United States and elsewhere. MSDV is a significant pathogen in confinement pheasant operations, causing significant economic losses. AAS is virtually ubiquitous among chicken flocks in the United States, in which case mild respiratory signs and splenomegaly are occasionally associated. The syndrome is similar to the disease state observed in pheasants, but in general AAS virus causes no significant problems among chickens. Evidence indicates that these group II avian adenoviruses are limited to the order Galliformes, and that wild bird populations (even wild turkeys) are unaffected. The more interesting group III adenoviruses first appeared in 1976 associated with a distinct clinical manifestation called egg drop syndrome (EDS), in which egg production decreases and thin-shelled or shell-less eggs are produced. The disease has caused significant egg production losses mostly in the Eurasian and Australian-Pacific poultry markets. A virus named EDS76, which has been found associated with this syndrome, may have been originally introduced via a contaminated vaccine, but it seems clear now that sporadic cases are initiated by introduction of the causative virus from domestic and wild waterfowl, mostly ducks and geese. When endemic in flocks, the virus is transmitted vertically and exhibits a latent phase, which is reactivated in laying hens, usually after egg production begins. The virus initially appears to replicate in lymphoid tissues but rapidly moves to the oviduct, where replication causes inflammation and production of aberrant eggs. Unlike other avian adenoviruses, the group III strains do not replicate in the intestinal mucosa. It is likely that EDS76 virus or very similar strains are present ubiquitously in wild ducks and geese, but rarely appear to be associated with disease.
CABT-CSY2603 is suitable for use in Suitable for use in Immunoassay application.
CABT-CSY2603 is supplied as a lyophilized formulation. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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