Anti-Adenovirus Hexon Monoclonal antibody (DMAB2938)

Mouse Anti-Adenovirus Hexon Monoclonal antibody for ELISA, IF, LFIA

Additional Formats Available

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
CIOD605
Species Reactivity
Adenovirus
Immunogen
Purified Adenovirus hexon
Conjugate
Unconjugated

Applications


Application Notes
ELISA, IF, LFIA
We recommend the following for sandwich ELISA and Lateral Flow assays (Capture - Detection):
DMAB2930 - DMAB2938
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Adeno_hexon; Adenovirus Hexon; Adenovirus hexon; Hexon protein; Late protein 2; PII

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Differential expression of T(HELPER)1 cytokines upon antigen stimulation predicts ex vivo proliferative potential and cytokine production of virus-specific T cells following re-stimulation

TRANSPLANT INFECTIOUS DISEASE

Authors: Feucht, J.; Leibold, J.; Halder, A.; Kayser, S.; Hartl, L.; Rammensee, H. -G.; Handgretinger, R.; Feuchtinger, T.

IntroductionCytomegalovirus (CMV) and human adenovirus (ADV) infections are causes of morbidity after stem cell transplantation. Antigen (Ag)-specific T cells are essential for the control of viral infections. However, in vivo expansion potential of T-cell subpopulations is hardly predictable in humans. Furthermore, ex vivo identification of human T cells with repopulating capacity for adoptive T-cell transfer has been difficult. MethodsWe analyzed Ag-specific T-cell populations, subdivided according to the expression of different T(HELPER-)1 (Th1) cytokines. Isolation by flow cytometry was based on interferon-gamma (IFN)-, interleukin (IL)-2, or tumor necrosis factor-alpha (TNF-) secretion of T cells after ex vivo stimulation with the Ags hexon (for ADV) and pp65 (for CMV). Isolated T cells were expanded and examined for functional characteristics, expansion/differentiation potential, and naive, effector memory, central memory, and late effector phenotypes. ResultsIsolation based on IFN- production provides a T-cell population with a mixture of early, central memory, and effector memory T cells, high expansion potential, and effective cytokine production. Selection of T cells with Ag-specific expression of IL-2 or TNF-, however, results in a T-cell population with reduced proliferation and lower effector potential after expansion. ConclusionWe conclude that the exclusive secretion of IFN- in the human antiviral T-cell responses preferentially leads to higher repopulation capacities of antiviral T cells, compared to IL-2 or TNF- secreting T-cell populations.

Associations of Adenovirus Genotypes in Korean Acute Gastroenteritis Patients with Respiratory Symptoms and Intussusception

BIOMED RESEARCH INTERNATIONAL

Authors: Kim, Jae-Seok; Lee, Su Kyung; Ko, Dae-Hyun; Hyun, Jungwon; Kim, Han-Sung; Song, Wonkeun; Kim, Hyun Soo

Human adenoviruses (HAdVs) cause a wide range of diseases, including respiratory infections and gastroenteritis, and have more than 65 genotypes. To investigate the current genotypes of circulating HAdV strains, we performed molecular genotyping of HAdVs in the stool from patients with acute gastroenteritis and tried to determine their associations with clinical symptoms. From June 2014 to May 2016, 3,901 fecal samples were tested for an AdV antigen, and 254 samples (6.5%) yielded positive results. Genotyping using PCR and sequencing of the capsid hexon gene was performed for 236 AdV antigen-positive fecal specimens. HAdV-41, of species F, was the most prevalent genotype (60.6%), followed by HAdV-2 of species C (13.8%). Other genotypes, including HAdV3, HAdV-1, HAdV-5, HAdV-6, HAdV-31, HAdV-40, HAdV-12, and HAdV-55, were also detected. Overall, 119 patients (50.4%) showed concomitant respiratory symptoms, and 32 patients (13.6%) were diagnosed with intussusception. HAdV-1 and HAdV-31 were significantly associated with intussusception (p < 0.05). Our results demonstrate the recent changes in trends of circulating AdV genotypes associated with gastroenteritis in Korea, which should be of value for improving the diagnosis and developing new detection, treatment, and prevention strategies for broad application in clinical laboratories.

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