A hybrid scheme of single relaxation time lattice Boltzmann and finite volume methods coupled with discrete ordinates method for combined natural convection and volumetric radiation in an enclosure
JOURNAL OF COMPUTATIONAL APPLIED MECHANICS
Authors: Soualmi, Rabiaa; Benbrik, Abderrahmane; Lemonnier, Denis; Cherifi, Mohammed; Bouanani, Mohammed
Abstract
This paper is focused on the application of hybrid Single relaxation time lattice Boltzmann and finite volume methods in conjunction with discrete ordinates method to simulate coupled natural convection and volumetric radiation in differentially heated enclosure, filled with an absorbing, emitting and non-scattering gray medium. In this work, the velocity and temperature fields are calculated using lattice Boltzmann and finite volume methods respectively, whereas the radiative term is computed by the discrete ordinates method. This study is carried out for Pr = 0.71, a Rayleigh number range of 10(3) <= Ra <= 10(6), an optical thickness with values 0 <= tau <= 100, a Planck number ranging in 0.001 <= Pl <= 100 and an aspect ratio varying between 0.5 <= Ar <= 2. Results are presented in terms of streamlines, isotherms, velocity profiles and average Nusselt number. Based on the obtained results, it can be concluded that the presence of volumetric radiation is noteworthy. Its effect, as a function of Rayleigh number and the radiative properties, yields significant changes on the behavior of streamlines and isotherms. In the taller enclosure, the increase of average total Nusselt number with increasing Rayleigh number is less significant than that in the case of the shallow enclosure.
olMounting evidence of FKBP12 implication in neurodegeneration
NEURAL REGENERATION RESEARCH
Authors: Caminati, Gabriella; Procacci, Piero
Abstract
Intrinsically disordered proteins, such as tau or alpha-synuclein, have long been associated with a dysfunctional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' diseases, these proteins, sharing a common chemical-physical pattern with alternating hydrophobic and hydrophilic domains rich in prolines, abnormally aggregate in tangles in the brain leading to progressive loss of neurons. In this review, we present an overview linking the studies on the implication of the peptidyl-prolyl isomerase domain of immunophilins, and notably FKBP12, to a variety of neurodegenerative diseases, focusing on the molecular origin of such a role. The involvement of FKBP12 dysregulation in the aberrant aggregation of disordered proteins pinpoints this protein as a possible therapeutic target and, at the same time, as a predictive biomarker for early diagnosis in neurodegeneration, calling for the development of reliable, fast and cost-effective detection methods in body fluids for community-based screening campaigns.
COA
Publication 
 monoclonal Antibody, clone FQS3500.jpg)
 monoclonal Antibody, clone FQS3407.jpg)
 Antibody_1.gif)
Loading ......
