Specifications
Species Reactivity
Bovine; Human; Mouse; Rat
Immunogen
Native purified bovine MAPT.
Applications
Application Notes
WB (0.5-1 μg/mL); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 μg/mL) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
microtubule-associated protein tau; PPND; MTBT1; Neurofibrillary tangle protein; TAU; Paired helical filament-tau; MSTD; FLJ31424; PHF-tau; FTDP-17; DDPAC; MGC138549; MTBT2; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; OTTHUMP00000239567; O
Product Background
Antigen Description
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer"s disease, Pick"s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Mouse monoclonal antibody raised against native MAPT.
Pathway
Alzheimer"s disease, organism-specific biosystem; Alzheimer"s disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic execution phase, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem
Citations
Publication ()
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COA
 monoclonal Antibody, clone FQS3500.jpg)
 monoclonal Antibody, clone FQS3407.jpg)
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