Magic™ Anti-Tau monoclonal antibody (DCABH-209)

Rabbit Anti-Human Tau (Phospho S396) monoclonal antibody for IHC-P, WB, IP

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS3842
Species Reactivity
Mouse, Rat, Human
Immunogen
A phospho specific peptide corresponding to residues surrounding serine 396 of Human Tau.
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF: 1/50; IHC-P: 1/4000; WB: 1/10000 - 1/50000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MAPT; microtubule-associated protein tau; DDPAC, MAPTL; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1
Entrez Gene ID
UniProt ID

Product Background


Pathway
Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem; IL-6 Signaling Pathway, organism-specific biosystem;

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


AMOEBA binding free energies for the SAMPL7 TrimerTrip host-guest challenge

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Authors: Shi, Yuanjun; Laury, Marie L.; Wang, Zhi; Ponder, Jay W.

As part of the SAMPL7 host-guest binding challenge, the AMOEBA force field was applied to calculate the absolute binding free energy for 16 charged organic ammonium guests to the TrimerTrip host, a recently reported acyclic cucurbituril-derived clip host structure with triptycene moieties at its termini. Here we report binding free energy calculations for this system using the AMOEBA polarizable atomic multipole force field and double annihilation free energy methodology. Conformational analysis of the host suggests three families of conformations that do not interconvert in solution on a time scale available to nanosecond molecular dynamics (MD) simulations. Two of these host conformers, referred to as the "indent" and "overlap" structures, are capable of binding guest molecules. As a result, the free energies of all 16 guests binding to both conformations were computed separately, and combined to produce values for comparison with experiment. Initial ranked results submitted as part of the SAMPL7 exercise had a mean unsigned error (MUE) from experimental binding data of 2.14 kcal/mol. Subsequently, a rigorous umbrella sampling reference calculation was used to better determine the free energy difference between unligated "indent" and "overlap" host conformations. Revised binding values for the 16 guests pegged to this umbrella sampling reference reduced the MUE to 1.41 kcal/mol, with a correlation coefficient (Pearson R) between calculated and experimental binding values of 0.832 and a rank correlation (Kendall tau) of 0.65. Overall, the AMOEBA results demonstrate no significant systematic error, suggesting the force field provides an accurate energetic description of the TrimerTrip host, and an appropriate balance of solvation and desolvation effects associated with guest binding.

Robustness of the Pairwise Kinematic Sunyaev-Zeldovich Power Spectrum Shape as a Cosmological Gravity Probe

ASTROPHYSICAL JOURNAL

Authors: Zheng, Yi

We prove from the modified gravity (MG) galaxy/halo mock catalogs that the shape of the pairwise kinematic Sunyaev-Zeldovich (kSZ) power spectrum P-kSZ has constraining power on discriminating different gravity theories on cosmological scales. By varying the effective optical depth tau(T) as a free parameter, we verify that the tau(T)-f (the linear growth rate) degeneracy in the linear theory of P-kSZ is broken down by the nonlinear structure growth and the scale dependence of f in some MG theories. Equivalently speaking, the shape of P-kSZ alone could be used to tightly constrain the MG theories on cosmological scales. With good knowledge of galaxy density biases, we verify that a combination of the next-generation galaxy spectroscopic redshift and CMB surveys, e.g., BOSS+CMB-S4 or DESI+CMB-S4, could potentially discriminate f(R) models from the general relativity at the similar to 5 sigma level using the shape of the galaxy pairwise kSZ dipole P-kSZ,P-l = 1 alone, when f(R0) = 10(-4).

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