Magic™ Anti-MAPT (Phospho T50) monoclonal Antibody, clone FQS3407

Two solubility limited pharmaceuticals bezafibrate and fenofibrate, belonging to BCS class II drugs, were compared, by investigating molecular dynamics of the former and compared with the neat and as a probe in an apolar host polystyrene of mole. wt. 800 (PS800) of the latter by broadband dielectric spectroscopy (BDS), other supporting thermal and spectroscopic experimental means and density functional theory (DFT) calculations. The BDS experiments from frozen glassy state to vibrant molten state of the title drugs were done to explore the role of parameters describing their complex molecular dynamics and the stabiliy of amorphous phase, such as glass transition temperature (Tg), temperature dependence of alpha-relaxation times (tau alpha), width of structural dispersion and its role on the occurrence of Johari-Goldstein (JG) beta-relaxation, fragility index (m) and apparent activation energy of secondary processes. Realizing that most of the pharmaceuticals have narrow alpha-dispersion which limits the visibility of JG beta-relaxation as a separate process in the dielectric window, to resolve the conundrum, we have further explored the amorphous dynamics of fenofibrate as a probein an apolar host polystyrene of molecular weight 800 (PS800) having higher Tg than the polar probe. The Tg of bezafibrate and PS800-fenofibrate mixture were determined to be 298 K and 275 K respectively, whereas the fractional exponent of Kohlrausch-Williams-Watts function beta KWW of bezafibrate was determined to be 0.68 which is closer to that of fenofibrate, whereas that of PS800-fenofibrate mixture was found to be much broader with a value of 0.39, all in the vicinity of Tg. Even though beta KWW decreased in binary mixture of fenofibrate when compared to its pure form due to concentration fluctuations and other aspects, but cold crystallization tendency was absent and Tg is elevated than that of fenofibrate. Due to higher Tg than that of fenofibrate, amorphous bezafibrate is more stable than fenofibrate. Finally, using quantum computational calculations using DFT, the relevant flexible parts of the two drug molecules, whose motions manifests the secondary gamma-relaxation was identified by calculating potential energy barriers and dipole moments on relaxed dihedral angle scans, as no experimental technique is available for this purpose.

We apply the general formalism derived by Penalva et al. [Phys. Rev. D 101, 113004 (2020)] to the semileptonic decay of pseudoscalar mesons containing a b quark. While present (B) over bar -> D-(*()) data give the strongest evidence in favor of lepton flavor universality violation, the observables that are normally considered are not able to distinguish between different new physics (NP) scenarios. In the above reference we discussed the relevant role that the various contributions to the double differential decay widths d(2)Gamma (d omega d cos theta(l)) and d(2)Gamma (d omega dE(l)) could play to this end. Here omega is the product of the two hadron fourvelocities, theta(l) is the angle made by the final lepton and final hadron three-momenta in the center of mass of the final two-lepton system, and E-l is the final charged lepton energy in the laboratory system. The formalism was applied by Penalva et al. to the analysis of the Lambda(b) -> Lambda(c) semileptonic decay, showing the new observables were able to tell apart different NP scenarios. Here we analyze the (B) over barc -> eta(c)tau(nu) over bar (tau), (B) over barc -> J/psi tau(nu) over bar (tau), (B) over bar -> D tau(nu) over bar (tau) and (B) over bar -> D*tau(nu) over bar (tau) , semileptonic decays. We find that, as a general rule, the (B) over barc -> J/psi observables, even including (tau) polarization, are less optimal for distinguishing between NP scenarios than those obtained from (B) over barc -> eta(c) decays, or those presented by Penalva et al. for the related Lambda(b) -> Lambda(c) semileptonic decay. Finally, we show that (B) over bar -> D and (B) over barc -> eta(c) , and (B) over bar -> D* and (B) over barc -> J/psi decay observables exhibit similar behaviors.