Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Shi, Q; Gao, ZY; et al. A NOVEL MONOCLONAL ANTIBODY AGAINST HUMAN CD80 AND ITS IMMUNE PROTECTION IN A MOUSE LUPUS-LIKE DISEASE. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 24:583-593(2011).
Ford, ML; Larsen, CP; et al. Translating costimulation blockade to the clinic: lessons learned from three pathways. IMMUNOLOGICAL REVIEWS 229:294-306(2009).
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